Anti-inflammatory agent 47 NEW
| Price | $1520 | $1980 | $2500 |
| Package | 25mg | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: Anti-inflammatory agent 47 | CAS No.: 2925288-12-4 |
| Supply Ability: 10g | Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | Anti-inflammatory agent 47 |
| Description | Flo8, an anti-inflammatory and antioxidant agent, effectively suppresses the release of reactive oxygen species (ROS) and nitric oxide (NO) while inhibiting neuronal apoptosis by modulating inflammatory and apoptotic signaling pathways, showcasing potential utility in Parkinson's Disease (PD) research [1]. |
| In vitro | Compound Flo8, at concentrations of 5 μM and 10 μM administered for 18 hours, exhibited minimal inhibitory effects on the viability of BV2 microglial cells [1]. Furthermore, at a concentration of 5 μM over 18 hours, it significantly inhibited the production of reactive oxygen species (ROS) in BV2 cells [1]. The same concentrations of Compound Flo8 over 18 hours also reduced the expression of inflammatory cytokines in BV2 cells, consequently decreasing apoptosis levels in SH-SY5Y cells [1]. Additionally, Compound Flo8 inhibited M1 polarization and promoted M2 polarization in microglia following LPS induction at 5 μM and 10 μM for 18 hours [1]. It also suppressed the phosphorylation of ERK, p38, and JNK in BV2 cells induced by LPS [1]. |
| In vivo | Compound Flo8 (15/35 mg/kg, intraperitoneal injection, daily/biweekly) alleviates neuroinflammation and inhibits neuronal apoptosis in the brains of MPTP-induced C57BL/6J mice [1]. |
| Storage | Shipping with blue ice. |
| Inhibitors Related | Sodium Thiocyanate | Imeglimin hydrochloride | Acetylcysteine | L-Ascorbic acid | α-Vitamin E | Ammonium sulfate | Glucosamine | D-(+)-Glucono-1,5-lactone | Tempol | Lycopene | Coenzyme Q10 | Naringenin |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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| Product name | Price | Suppliers | Update time | |
|---|---|---|---|---|
| $52.00/5mg |
VIP5Y
|
TargetMol Chemicals Inc.
|
2024-11-19 | |
| $2.00/1kg |
Wuhan Xinhao Biotechnology Co., Ltd
|
2024-01-15 |
United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
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