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AMG 510 CAS:2252403-56-6 Pharmaceutical Raw Materials  

Product Name:AMG 510

Synonyms:6-FLUORO-7-(2-FLUORO-6-HYDROXYPHENYL)-1-[4-METHYL-2-(PROPAN-2-YL)PYRIDIN-3-YL]-4-[(2S)-2-METHYL-4-(P;6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-[4-methyl-2-(propan-2-yl)pyridin-3-yl]-4-[(2S)-2-methyl-4-(prop-2-enoyl)piperazin-1-yl]-1H,2H-pyrido[2,3-d]pyrimidin-2-one;AMG-510;AMG 510;AMG510;AMG 510;4-((S)-4-acryloyl-2-methylpiperazin-1-yl)-6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-(2-isopropyl-4-methylpyridin-3-yl)pyrido[2,3-d]pyrimidin-2(1H)-one;chiral AMG 510, single isomer;CPD2809;AMG-510，AMG510

CAS:2252403-56-6

MF:C30H30F2N6O3

MW:560.59

Boiling point:730.5±70.0 °C(Predicted)

density:1.36±0.1 g/cm3(Predicted)

storage temp.:Store at -20°C, stored under nitrogen

solubility:DMSO:75.0(Max Conc. mg/mL);133.78(Max Conc. mM)

Water:33.33(Max Conc. mg/mL);59.45(Max Conc. mM)

Ethanol:8.0(Max Conc. mg/mL);14.27(Max Conc. mM)

Storage:-20°C, stored under nitrogen

Uses:AMG-510 is a KRAS G12C inhibitor thus leading to the regression of KRAS G12C tumors as it interrupts protein signaling.

Description   

AMG-510 is a first-in-class, orally bioavailable, and selective KRAS G12C covalent inhibitor. AMG-510 irreversibly inhibits KRAS G12C by locking it in an inactive GDP-bound state. AMG-510 is the first KRAS G12C inhibitor in clinical development and leads to the regression of KRAS G12C tumors.

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Hebei Mojin Biotechnology Co., Ltd, Our company is a professional in 4'-Methylacetophenone,Levamisole hydrochloride ,N-Methylformamide and other chemical reagents research and development production enterprises. Our business covers more than 30 countries, most of the big customers come from Europe, America and other countries in the world, we can guarantee the quality and price. In recent decades, with the efforts of all employees, we have established many cooperative companies in shandong, henan, guangdong and other places. Our corporate purpose is based on the market, enhance the strength, take the road of scientific and environmental sustainable development, relying on the country. Technology r & d center, increase the investment in r & d, based on the domestic market, expand the international market, manufacturing quality products, sincere service to the society, into a modern, ecological, scientific and technological enterprise world.