Alexidine dihydrochloride NEW
| Price | $54 | $72 | $101 |
| Package | 25mg | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: Alexidine dihydrochloride | CAS No.: 1715-30-6 |
| Purity: 98.31% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | Alexidine dihydrochloride |
| Description | Alexidine dihydrochloride has antifungal and antibiofilm activity against a diverse range of fungal pathogens. Alexidine dihydrochloride is an anticancer agent that targets a mitochondrial tyrosine phosphatase, PTPMT1, in mammalian cells and causes mitochondrial apoptosis. Thus, Alexidine dihydrochloride has the potential to be developed as a pan-antifungal, antibiofilm drug. |
| In vitro | Alexidine dihydrochloride effectively eliminates mature biofilms of Candida, Cryptococcus, and Aspergillus spp., which are typically resistant to nearly all antifungal drugs, at low concentrations (1.5 to 6?μg/mL). It exhibits potent activity against most strains of Candida, achieving minimum inhibitory concentrations (MIC) of ≤1.5?μg/mL for all tested isolates in planktonic form, except for Candida parapsilosis and Candida krusei. Notably, it also demonstrates significant effectiveness against fluconazole-resistant Candida isolates, including strains of C. albicans, C. glabrata, C. parapsilosis, and C. auris. Furthermore, Alexidine dihydrochloride prevents the growth and spread of fungi by entirely inhibiting filamentation and biofilm dispersal, specifically at concentrations significantly lower than those harmful to human cells (150?ng/mL versus 5- to 10-fold higher concentrations for 50% killing of HUVECs and lung epithelial cells). |
| In vivo | The study primarily investigates biofilm formation by C. Albicans, leveraging an established murine biofilm model for evaluating both existing and novel antifungal compounds. Alexidine dihydrochloride is highlighted for its efficacy, inhibiting 67% of fungal biofilm growth and viability in comparison to control groups, as evidenced by fungal colony-forming unit (CFU) counts. Additionally, microscopic examination of 24-hour-old biofilms within mice jugular vein catheters demonstrates a considerably reduced biofilm density when treated with Alexidine dihydrochloride[1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 250 mg/mL (429.77 mM), Sonication is recommended. |
| Keywords | anticancer | antibiofilm | Fungal | mitochondrial | AXD | antifungal | phosphatase | Alexidine Dihydrochloride | Alexidine dihydrochloride | tyrosine | inhibit | PTPMT1 | Alexidine | Apoptosis | Inhibitor |
| Inhibitors Related | Stavudine | Dehydroacetic acid sodium | Potassium gluconate | 5-Fluorouracil | Myricetin | Sodium 4-phenylbutyrate | L-Ascorbic acid | Metronidazole | Tributyrin | Geraniol | Salicylic acid | Oleic acid |
| Related Compound Libraries | Apoptosis Compound Library | Bioactive Compound Library | Anti-Fungal Compound Library | Mitochondria-Targeted Compound Library | NO PAINS Compound Library | Bioactive Compounds Library Max | Anti-Cancer Compound Library | Anti-Infection Compound Library | Anti-Cancer Active Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
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