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Postion:Product Catalog >AGK7
AGK7
  • AGK7

AGK7 NEW

Price $65 $125 $215
Package 1mg 5mg 10mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-19

Product Details

Product Name: AGK7 CAS No.: 304896-21-7
Purity: 98.31% Supply Ability: 10g
Release date: 2024/11/19

Product Introduction

Bioactivity

NameAGK7
DescriptionAGK7 is an inactive control of AGK2, a selective SIRT2 inhibitor that selectively inhibits SIRT3 over SIRT1 and SIRT2 (IC50 = >5 μM, >50 μM and >50 μM for SIRT3, SIRT1, and SIRT2, respectively).
In vitroAGK2 is a selective SIRT2 inhibitor with IC50 value of 3.5 μM. AGK2 slightly inhibited SIRT1 and 3 only at concentrations over 40 μM. Relative to an inactive control AGK7, AGK2 increased acetylated tubulin. In H4 cells transfected with α-Syn, AGK2 reduced α-Syn-mediated toxicity in a dose-dependent way. By contrast, the inactive AGK7 had no effect. In H4 cells cotransfected withα-Syn and synphilin-1, the inactive AGK7 failed to affect a-Syn aggregation, whereas AGK2 promoted the formation of enlarged inclusions [1].
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility InformationDMSO : 0.5 mg/mL
KeywordsParkinson's disease | sirtuin 2 | morphology | SIRT2 Inhibitor,Inactive Control | Drosophila | inhibit | toxicity | Inhibitor | alpha-synuclein | dopaminergic cell death | AGK7 | AGK 7 | AGK-7 | Sirtuin
Inhibitors RelatedJGB1741 | Sirtinol | Dihydrocoumarin | Resveratrol | SRT 2104 | Nicotinamide riboside | MC3482 | SIRT6-IN-5 | Salvianolic acid B | Fisetin | 3-TYP | Nicotinamide
Related Compound LibrariesEpigenetics Compound Library | NO PAINS Compound Library

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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