A 68930 hydrochloride NEW
| Price | $494 |
| Package | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: A 68930 hydrochloride | CAS No.: 130465-39-3 |
| Supply Ability: 10g | Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | A 68930 hydrochloride |
| Description | A68930 hydrochloride is a dopamine D1 receptor agonist which can be used for the research of bronchiectasis [1]. |
| In vitro | The dopamine D1 receptor protein presence was confirmed in the native human airway epithelium and in three types of cultured human airway epithelial cells. Treatment with A68930 hydrochloride (1 μM) across varying durations (5-60 minutes for 16HBE14o- or NCI-H292 cells; 48 hours for NCI-H292 cells) demonstrated significant biochemical changes. Notably, a brief exposure (1 μM; 5-60 minutes) in 16HBE14o- or NCI-H292 cells markedly enhanced the phosphorylation of cAMP response element-binding (CREB) protein, as evidenced by Western Blot Analysis. Prolonged exposure (1 μM; 48 hours) in NCI-H292 cells was found to induce MUC5AC mRNA expression, simultaneously boosting both the mRNA levels and protein expression of MUC5AC, confirmed through RT-PCR and Immunofluorescence techniques. Furthermore, a short exposure (1 μM; 20 minutes) in NCI-H292 cells significantly increased intracellular cAMP levels, indicating the compound’s efficacy in activating intracellular signaling pathways critical in respiratory epithelial cell functions [1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Keywords | A 68930 hydrochloride | A68930 Hydrochloride | A 68930 Hydrochloride | A-68930 Hydrochloride |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
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