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3-[[4-[2-(3-chloroanilino)pyrimidin-4-yl]pyridin-2-yl]amino]propan-1-ol
| Price | $1 |
| Package | 1g |
| Min. Order: | 1g |
| Supply Ability: | 1ton |
| Update Time: | 2020-01-13 |
Product Details
| Product Name: 3-[[4-[2-(3-chloroanilino)pyrimidin-4-yl]pyridin-2-yl]amino]propan-1-ol | CAS No.: 164658-13-3 |
| EC-No.: 200-258-5 | Min. Order: 1g |
| Purity: 95-99% | Supply Ability: 1ton |
| Release date: 2020/01/13 | |
| contact: Mary@coreychem.com |
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Common Name
3-[[4-[2-(3-chloroanilino)pyrimidin-4-yl]pyridin-2-yl]amino]propan-1-ol
CAS Number
164658-13-3
Molecular Weight
355.82100
Density
1.356g/cm3
Boiling Point
630.6ºC at 760mmHg
Molecular Formula
C18H18ClN5O
Melting Point
N/A
MSDS
N/A
Flash Point
335.2ºC
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Use of 3-[[4-[2-(3-chloroanilino)pyrimidin-4-yl]pyridin-2-yl]amino]propan-1-ol
CGP60474 is a potent VEGFR-2 inhibitor, with an IC50 of 84 nM, and also an ATP-competitive PKC inhibitor.
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Name
3-[[4-[2-(3-chloroanilino)pyrimidin-4-yl]pyridin-2-yl]amino]propan-1-ol
Synonym
More Synonyms
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Description
CGP60474 is a potent VEGFR-2 inhibitor, with an IC50 of 84 nM, and also an ATP-competitive PKC inhibitor.
Related Catalog
Signaling Pathways >> Epigenetics >> PKC
Signaling Pathways >> TGF-beta/Smad >> PKC
Research Areas >> Cancer
Target
VEGFR-2:84 nM (IC50)
PKC
In Vitro
CGP60474 (Compound A) is a potent VEGFR-2 inhibitor, with an IC50 of 84 nM[1]. CGP60474 is also a PKC inhibitor, with competitive kinetics relative to ATP[2].
References
[1]. Kuo GH, et al. Synthesis and identification of [1,3,5]triazine-pyridine biheteroaryl as a novel series of potent cyclin-dependent kinase inhibitors. J Med Chem. 2005 Jul 14;48(14):4535-46.
[2]. Stanetty P, et al. Novel and efficient access to phenylamino-pyrimidine type protein kinase C inhibitors utilizing a Negishi cross-coupling strategy. J Org Chem. 2005 Jun 24;70(13):5215-20.
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Density
1.356g/cm3
Boiling Point
630.6ºC at 760mmHg
Molecular Formula
C18H18ClN5O
Molecular Weight
355.82100
Flash Point
335.2ºC
Exact Mass
355.12000
PSA
86.19000
LogP
3.22480
Vapour Pressure
9.02E-17mmHg at 25°C
Index of Refraction
1.685
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GNF-Pf-88
1-Propanol,3-((4-(2-((3-chlorophenyl)amino)-4-pyrimidinyl)-2-pyridinyl)amino)
UNII-16IP6G5MLC
CGP60474
Company Profile Introduction
Established in 2014,Career Henan Chemical Co. is a manufacturerspecializing in the sale of fine chemicals.
Mainly deals in the sales of:
Pharmaceutical intermediates
OLED intermediates：
Pharmaceutical intermediates;
OLED intermediates;
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China- Since: 2014-12-17
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