Estradiol 17-Valerate
Price | Get Latest Price |
Package | 1KG |
Min. Order: | 1g |
Supply Ability: | 1 ton |
Update Time: | 2021-03-17 |
Product Details
Product Name: Estradiol 17-Valerate | CAS No.: 979-32-8 |
Min. Order: 1g | Purity: 99.9% |
Supply Ability: 1 ton | Release date: 2021/03/17 |
簡介
Estradiol valerate (EV, E2V) (INN, USAN, JAN) (brand names Altadiol, Deladiol, Delestrogen, Estraval, Lastrogen, Progynova, Valergen, many others), or oestradiol valerate (BAN), is a synthetic ester, specifically the 17-pentanoyl ester, of the natural estrogen, 17β-estradiol. It was first introduced, as Delestrogen by Squibb in the United States, in 1954, and along with estradiol benzoate (1936) and estradiol cypionate (1952), has since become one of the most widely used esters of estradiol.
Upon ingestion, regardless of the route of administration, estradiol valerate behaves as a prodrug, being cleaved by esterases in blood plasma and the liver into 17β-estradiol and valeric acid. However, compared to estradiol itself, estradiol valerate is absorbed more slowly and possesses a longer duration, especially when given in an oil solution via intramuscular injection (in which it acts as a depot). As a result, it can be administered less frequently.
A single intramuscular injection of 4mg estradiol valerate results in maximal plasma levels of estradiol of about 390 pg/mL within three days of administration, with levels declining to 100 pg/mL by 12–13 days. A study of high-dose combined administration of 40mg estradiol valerate and 250mg hydroxyprogesterone caproate in women once weekly for six months (described as a "pseudopregnancy" regimen) found that serum levels of estradiol increased from 27.8–34.8 pg/mL to 3028–3226 pg/mL after three months and to 2491–2552 pg/mL after six months of treatment.
Upon ingestion, regardless of the route of administration, estradiol valerate behaves as a prodrug, being cleaved by esterases in blood plasma and the liver into 17β-estradiol and valeric acid. However, compared to estradiol itself, estradiol valerate is absorbed more slowly and possesses a longer duration, especially when given in an oil solution via intramuscular injection (in which it acts as a depot). As a result, it can be administered less frequently.
A single intramuscular injection of 4mg estradiol valerate results in maximal plasma levels of estradiol of about 390 pg/mL within three days of administration, with levels declining to 100 pg/mL by 12–13 days. A study of high-dose combined administration of 40mg estradiol valerate and 250mg hydroxyprogesterone caproate in women once weekly for six months (described as a "pseudopregnancy" regimen) found that serum levels of estradiol increased from 27.8–34.8 pg/mL to 3028–3226 pg/mL after three months and to 2491–2552 pg/mL after six months of treatment.
基本信息
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中文名稱
戊酸雌二醇
英文名稱
Estradiol 17-Valerate
中文別名
17-戊酸-Beta-雌二醇酯; 17-戊酸-β-雌二醇酯; 3,5(10)-三烯-17B-醇 17-戊酸酯; 17-戊酸-17-BETA-雌二酯; 3-羥基雌甾-1,3,5(10)-三烯-17b-醇 17-戊酸酯;
英文別名
Estradiol valerate;
CAS號
979-32-8
分子式
C23H32O3
分子量
356.49800
精確質量
356.23500
PSA
46.53000
LOGP
5.35030
物化性質
- 密度:
- 1.13g/cm3
- 沸點:
- 486.2ºC at 760mmHg
- 熔點:
- 144°C
- 閃點:
- 191.1ºC
- 折射率:
- 1.567
安全信息
- RTECS號:
- KG5793000
- 安全說明:
- S53-S45
- 危險類別碼:
- R60; R61
- WGK Germany:
- 3
- 危險品標志:
- T
Company Profile Introduction
Welcome to hebei Shuoxi biotechnology co., LTD. Shuoxi is a fast developing pharmaceutical intermediates enterprise located in shijiazhuang, capital of hebei province.
Shuoxi analysis research and development center also provides custom synthesis service.
Hebei Shuoxi biotechnology co., LTD can provide customized synthetic chemicals in different quantities in laboratories, factories and industrial scale.
We have more than 10 years experience in this field.
We can offer competitive price for every customer and guarantee the quality of our products.
3. We pay attention to the needs of each customer and build a good relationship with them.
4. We have long-term business relations with Canada, Mexico, Brazil, UK, Russia, Germany, USA, India, South Africa, Malta, Egypt, Armenia, Australia, Philippines, Belgium, Netherlands, Denmark and other countries.
If you have any other questions for me. Please feel free to contact me.
We only produce and sell products that are legal in China. All products are sold only to laboratory research.
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- Since: 2016-11-14
- Address: NO.108 ZHONGSHAN ROAD, QIAOXI DISTRICT, ShiJiazhuang CITY, CHINA
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