5-LOX-IN-2 NEW
| Price | $52 | $147 | $242 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-06-12 |
Product Details
| Product Name: 5-LOX-IN-2 | CAS No.: 179691-97-5 |
| Purity: 99.18% | Supply Ability: 10g |
| Release date: 2025/06/12 |
Product Introduction
Bioactivity
| Name | 5-LOX-IN-2 |
| Description | 5-LOx-in-2 is a 5-lipoxygenase inhibitor (5-LOX) with an IC50 value of 0.33 μM. 5-lox-in-2 inhibits 5-LOX action IN a dose-dependent manner. 5-LOX-IN-2 can reduce the cell activity of kidney cancer cells and induce apoptosis, and can be used in cancer research. |
| In vitro | 5-LOX-IN-2 at a concentration of 0-100 μM, after 4 days of action, reduced the activity of renal cancer cells (RCC4, RCC10, 786.0 cells) and showed higher selectivity for RCC4 and 786.0 cells deficient in the von Hippel-Lindau (VHL) tumor suppressor gene. 5-LOX-IN-2 at a concentration of 0-10 μM, after 24 hours of action, was capable of increasing the expression of LC3B and p62, and inducing apoptosis through the activation of the caspase-3 pathway. concentration and after 24 hours of action, it was able to increase the expression of LC3B and p62, block the autophagic flow in RCC4 cells, and induce apoptosis by activating the caspase-3 pathway. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 50 mg/mL (175.86 mM), Sonication is recommended. |
| Keywords | Apoptosis | 5-LOX-IN-2 | 5LOXIN2 | 5-LOX |
| Inhibitors Related | Stavudine | 5-Fluorouracil | Flubendazole | Cysteamine hydrochloride | Myricetin | Dextran sulfate sodium salt (MW 4500-5500) | Sodium 4-phenylbutyrate | L-Ascorbic acid | L-Glutamic acid | Tributyrin | L-Ascorbic acid sodium salt | Alginic acid |
| Related Compound Libraries | Apoptosis Compound Library | Bioactive Compound Library | Anti-Obesity Compound Library | Inhibitor Library | Lipid Metabolism Compound Library | Metabolism Compound Library | Bioactive Compounds Library Max | Anti-Cancer Compound Library | Anti-Cancer Active Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, MA
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