Cetirizine hydrochloride
| Price | $1 |
| Package | 1KG |
| Min. Order: | 1G |
| Supply Ability: | 100KG |
| Update Time: | 2019-07-06 |
Product Details
| Product Name: Cetirizine hydrochloride | CAS No.: 83881-52-1 |
| Min. Order: 1G | Purity: 98% |
| Supply Ability: 100KG | Release date: 2019/07/06 |
AD68
| Cetirizine hydrochloride Basic information |
| Description References |
| Product Name: | Cetirizine hydrochloride |
| Synonyms: | (2-(4-((4-chlorophenyl)phenylmethyl)-1-piperazinyl)ethoxy)aceticaciddihydro;2-[2-[4-[(4-chlorophenyl)-phenyl-methyl]piperazin-1-yl]ethoxy]acetic acid dihydrochloride;2-[4-(4-Chlorobenzhy;Cetrizide;Cetirizine Hydrochloride (250 mg);Alercet;Alerid;Cesta |
| CAS: | 83881-52-1 |
| MF: | C21H26Cl2N2O3 |
| MW: | 425.35 |
| EINECS: | 222-225-5 |
| Product Categories: | Histamine receptor;Aromatics;Heterocycles;Metabolites & Impurities;API;Aromatics, Heterocycles, Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals;DOPRAM;Active Pharmaceutical Ingredients;Intermediates & Fine Chemicals;Pharmaceuticals |
| Mol File: | 83881-52-1.mol |
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| Cetirizine hydrochloride Chemical Properties |
| Melting point | 110-115°C |
| storage temp. | Desiccate at RT |
| solubility | H2O: soluble5mg/mL, clear |
| color | white to beige |
| Water Solubility | Soluble in water, DMSO, ethanol, and methanol. |
| Merck | 14,2022 |
| CAS DataBase Reference | 83881-52-1(CAS DataBase Reference) |
| Safety Information |
| Hazard Codes | Xn,Xi |
| Risk Statements | 22-36/37/38 |
| Safety Statements | 26-36 |
| RIDADR | 3249 |
| WGK Germany | 3 |
| RTECS | AG0977500 |
| HazardClass | 6.1(b) |
| PackingGroup | III |
| Cetirizine hydrochloride Usage And Synthesis |
| Description | Cetirizine hydrochloride is an orally-active and selective histamine (H1)-receptor antagonist. It is a second-generation antihistamine and a human metabolite of hydroxyzine. Three important features of cetirizine are: a high specificity fort he H1-receptor; a low need for metabolism, and the existence of non-H1-dependent activities on cells involved in the pathogenesis of allergy. Cetirizine is used to treat seasonal allergic rhinitis (SAR), perennial allergic rhinitis, useful in treating urticaria and atopic dermatitis. Cetirizine possesses also mild anti-inflammatory effects. |
| References | [1] E. J. Corey and Christopher J. Helal, Catalytic Enantioselective Synthesis of the Second-Generation Histamine Antagonist Cetirizine Hydrochloride, Tetrahedron Letters, 1996, vol. 37, 4837-4840 [2] Jay M. Portnoy and Chitra Dinakar, Review of cetirizine hydrochloride for the treatment of allergic disorders, Journal of Expert Opinion on Pharmacotherapy, 2004, vol. 5, 125-135 |
| Chemical Properties | Crystalline Solid |
| Uses | respiratory stimulant |
| Uses | A nonsedating type histamine H1-receptor antagonist. A major metabolite of Hydroxyzine. Pharmacological activity resides primarily in the (R)-isomer. Antihystaminic. |
| Uses | long acting calcium channel blocker |
| Uses | Antihistaminic |
| Biological Activity | Histamine H 1 receptor antagonist that displays selectivity over other receptors at concentrations up to 10 μ M. A non-sedating antihistamine that inhibits histamine release and eosinophil chemotaxis during secondary phase allergic response. Inhibits activation of eosinophils, neutrophils and monocytes in vivo . |
Company Profile Introduction
Established in 2014,Career Henan Chemical Co. is a manufacturerspecializing in the sale of fine chemicals.
Mainly deals in the sales of:
Pharmaceutical intermediates
OLED intermediates：
Pharmaceutical intermediates;
OLED intermediates;
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China- Since: 2014-12-17
- Address: Zhengzhou High tech Zone, Henan Province, China
INQUIRY
楊俊青
sales@coreychem.com
sales@coreychem.com