Promethazine hydrochloride
| Price | $1 |
| Package | 1KG |
| Min. Order: | 1G |
| Supply Ability: | 100KG |
| Update Time: | 2019-07-06 |
Product Details
| Product Name: Promethazine hydrochloride | CAS No.: 58-33-3 |
| Min. Order: 1G | Purity: 98% |
| Supply Ability: 100KG | Release date: 2019/07/06 |
AD68
| Promethazine hydrochloride Basic information |
| Product Name: | Promethazine hydrochloride |
| Synonyms: | 10-(2-dimethylamino-1-propyl)phenothiazine hydrochloride;PROMETHAZINE HCL;PROMETHAZINE HYDROCHLORIDE;PHENERGAN;10-(2-(dimethylamino)propyl)phenothiazinemonohydrochloride;10-(2-(dimethylamino)propyl)-phenothiazinmonohydrochloride;10-(2-dimethylaminopropyl)phenothiazinehydrochloride;10-(3-dimethylaminoisopropyl)phenothiazinehydrochloride |
| CAS: | 58-33-3 |
| MF: | C17H21ClN2S |
| MW: | 320.88 |
| EINECS: | 200-375-2 |
| Product Categories: | Active Pharmaceutical Ingredients;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds;Histamine receptor;API;COLACE;Inhibitors |
| Mol File: | 58-33-3.mol |
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| Promethazine hydrochloride Chemical Properties |
| Melting point | 230-232°C |
| Fp | 9℃ |
| storage temp. | Refrigerator |
| λmax | 297nm(H2O)(lit.) |
| Merck | 14,7786 |
| InChIKey | XXPDBLUZJRXNNZ-UHFFFAOYSA-N |
| CAS DataBase Reference | 58-33-3(CAS DataBase Reference) |
| EPA Substance Registry System | 10H-Phenothiazine- 10-ethanamine, N,N,.alpha.-trimethyl-, monohydrochloride(58-33-3) |
| Safety Information |
| Hazard Codes | Xn,N |
| Risk Statements | 22-36/37/38-51/53-43-20/22 |
| Safety Statements | 26-36-61-60-36/37/39-28-22 |
| RIDADR | UN 2811 6.1/PG 3 |
| WGK Germany | 3 |
| RTECS | SO8225000 |
| HazardClass | 6.1(b) |
| PackingGroup | III |
| Toxicity | LD50 i.v. in mice: 55.0 mg/kg (Rajsner) |
| Promethazine hydrochloride Usage And Synthesis |
| Chemical Properties | White Solid |
| Uses | Antihistaminic, antiemetic, CNS depressant |
| Uses | stool softener |
| Uses | For the treatment of allergic disorders, and nausea/vomiting. |
| Definition | ChEBI: The hydrochloride salt of promethazine. |
| Uses | Promethazine is a first generation histamine H1 receptor antagonist (Ki = 2.6 nM) whose antihistamine activity has been reported in guinea pigs and mice at ED50 values of 0.43 and 5.9 mg/kg, respectively. Promethazine can penetrate the CNS, depressing central H1 receptor activity, which may relate to its sedative properties, and can also inhibit muscarinic acetylcholine receptors (Ki = 22 nM). Furthermore, 32 mg/kg promethazine demonstrates antiemetic effects in ferret models of motion sickness or chemotherapy-induced nausea. |
| General Description | Odorless white to faint yellow crystalline powder. Bitter taste. A 10% solution in water has a pH of 3.5-5.0. |
| Air & Water Reactions | Slowly oxidizes in air, acquiring a blue color. Also turns blue on exposure to moisture. Water soluble. |
| Reactivity Profile | Promethazine hydrochloride is sensitive to light. In aqueous solution, Promethazine hydrochloride is degraded by heat and light (more rapidly in air or oxygen). Incompatible with alkalis and alkaline solutions such as those of aminophylline, soluble barbiturates and phenytoin sodium. Iron(III) and copper(III) accelerate the degradation . |
| Fire Hazard | Flash point data for Promethazine hydrochloride are not available; however, Promethazine hydrochloride is probably combustible. |
Company Profile Introduction
Established in 2014,Career Henan Chemical Co. is a manufacturerspecializing in the sale of fine chemicals.
Mainly deals in the sales of:
Pharmaceutical intermediates
OLED intermediates：
Pharmaceutical intermediates;
OLED intermediates;
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China- Since: 2014-12-17
- Address: No.967,15th Floor,Unit 7, Building 1, No.70 of DianChang Road, High-tech Development Zone, Zhengzho
INQUIRY
楊俊青
sales@coreychem.com
sales@coreychem.com