ChemicalBook CAS DataBase List 2,6-Difluorobenzamide

2,6-Difluorobenzamide synthesis

13synthesis methods

Product Name:2,6-Difluorobenzamide
CAS Number:18063-03-1
Molecular formula:C7H5F2NO
Molecular Weight:157.12

2,6-Difluorobenzamide is obtained by hydrolysis of 2,6-difluorobenzonitrile.

1897-52-5 Synthesis

1897-52-5
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18063-03-1
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Yield:18063-03-1 91.2%

Reaction Conditions:

with dihydrogen peroxide;sodium hydroxide at 50; for 5 h;Temperature;

Steps:

1.2; 2-10; 11-13; 14-20; 21-23; 24.2; 25.2; 26

(2) Add 30g (0.214mol) of 2,6-difluorobenzonitrile obtained in step (1) into a four-necked flask with stirring, thermometer and reflux condenser,25.62g (0.128mol) of 20% sodium hydroxide solution, heated to 50°C,Under stirring, add 72.61g (0.641mol) of 30wt% hydrogen peroxide dropwise, add dropwise for 3h, keep for 2h, and carry out the hydrolysis reaction; After the reaction is completed, the temperature drops to 25°C, add 10wt% hydrochloric acid to adjust the pH value to neutral (about 7.0), keep the temperature and stir for 1.5h,Cooling and suction filtration, adding water to wash the filter cake, and drying to obtain a solid product of 2,6-difluorobenzamide.

References:

CN112851539,2021,A Location in patent:Paragraph 0074; 0080-0081; 0082-0085; 0086-0090; 0091-0094