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Diphenhydramine Hydrochloride
Price | $20 |
Package | 1Kg/Bag |
Min. Order: | 1Kg/Bag |
Supply Ability: | 20 Tons |
Update Time: | 2020-11-16 |
Product Details
Product Name: Diphenhydramine Hydrochloride | CAS No.: 147-24-0 |
EC-No.: 205-687-2 | Min. Order: 1Kg/Bag |
Purity: 99% | Supply Ability: 20 Tons |
Release date: 2020/11/16 |
Diphenhydramine Hydrochloride Basic information |
Description Clinical Pharmacology Indications and Usage Drug overdose Contraindications |
Product Name: | Diphenhydramine Hydrochloride |
Synonyms: | 2-(diphenylmethoxy)-n,n-dimethyl-ethanaminhydrochloride;2-(diphenylmethoxy)-n,n-dimethyl-ethylaminhydrochloride;Actifed;alpha-Hydroxydiphenylmethane-beta-dimethylaminoethyl ether hydrochloride;alpha-hydroxydiphenylmethane-beta-dimethylaminoethyletherhydrochloride;Ambenyl;BAX;Benacine |
CAS: | 147-24-0 |
MF: | C17H22ClNO |
MW: | 291.82 |
EINECS: | 205-687-2 |
Product Categories: | Anilines, Aromatic Amines and Nitro Compounds;API intermediates;Amines;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals;Histamine receptor;BENADRIL;Other APIs;On the central nervous activity inhibition of sedative hypnotic effect;API;Pharmaceutical intermediates |
Mol File: | 147-24-0.mol |
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Diphenhydramine Hydrochloride Chemical Properties |
Melting point | 168-172 °C |
Fp | 9℃ |
storage temp. | Desiccate at RT |
form | Crystalline Powder or Adhering Crystals |
color | White |
Water Solubility | 1000 g/L |
Sensitive | Light Sensitive |
Merck | 14,3309 |
Stability: | Stable, but slowly darkens upon exposure to light. Incompatible with strong oxidizing agents. |
InChIKey | PCHPORCSPXIHLZ-UHFFFAOYSA-N |
CAS DataBase Reference | 147-24-0(CAS DataBase Reference) |
NIST Chemistry Reference | diphenhydramine hydrochloride(147-24-0) |
EPA Substance Registry System | Ethanamine, 2-(diphenylmethoxy)-N,N-dimethyl-, hydrochloride(147-24-0) |
Safety Information |
Hazard Codes | Xn,T,F |
Risk Statements | 22-39/23/24/25-23/24/25-11 |
Safety Statements | 36-45-36/37-16-7-24/25 |
RIDADR | 2811 |
WGK Germany | 3 |
RTECS | KR7000000 |
Toxicity | LD50 orally in rats: 500 mg/kg (Gruhzit, Fisken) |
Diphenhydramine Hydrochloride Usage And Synthesis |
Description | Diphenhydramine hydrochloride is an antihistamine drug having the chemical name 2-(Diphenylmethoxy)- N,N-dimethylethylamine hydrochloride. It occurs as a white, crystalline powder, is freely soluble in water and alcohol and has a molecular weight of 291.82. The molecular formula is C17H21NO·HCl and the structural formula is as follows: ![]() Diphenhydramine hydrochloride in the parenteral form is a sterile, pyrogen-free solution available in a concentration of 50 mg of diphenhydramine hydrochloride per mL. The solutions for parenteral use have been adjusted to a pH between 5.0 and 6.0 with either sodium hydroxide or hydrochloric acid and contains 0.1 mg/mL benzethonium chloride as a germicidal agent. |
Clinical Pharmacology | Diphenhydramine hydrochloride is an antihistamine with anticholinergic (drying) and sedative side effects. Antihistamines appear to compete with histamine for cell receptor sites on effector cells. Diphenhydramine hydrochloride in the injectable form has a rapid onset of action. Diphenhydramine hydrochloride is widely distributed throughout the body, including the CNS. A portion of the drug is excreted unchanged in the urine, while the rest is metabolized via the liver. Detailed information on the pharmacokinetics of Diphenhydramine Hydrochloride Injection is not available. |
Indications and Usage | Diphenhydramine hydrochloride in the injectable form is effective in adults and pediatric patients, other than premature infants and neonates, for the following conditions when diphenhydramine hydrochloride in the oral form is impractical.
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Drug overdose | Antihistamine overdosage reactions may vary from central nervous system depression to stimulation. Stimulation is particularly likely in pediatric patients. Atropine-like signs and symptoms; dry mouth; fixed, dilated pupils; flushing; and gastrointestinal symptoms may also occur. Stimulants should not be used. Vasopressors may be used to treat hypotension. |
Contraindications |
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Chemical Properties | white crystalline powder |
Uses | Diphenhydramine is a H1-histamine receptor antagonist. Diphenhydramine is categorized as an antihistaminic; sedative, hypnotic. |
Uses | antihistamine, sedative, treatment of allergic |
Uses | A histamine H1-receptor antagonist. |
Uses | H1-Histamine receptor antagonist. Antihistaminic; sedative, hypnotic |
Definition | ChEBI: The hydrochloride salt of diphenhydramine. |
General Description | White or almost-white crystalline powder. Odorless with a bitter numbing taste. pH (5% aqueous solution) 4-6. |
Air & Water Reactions | Water soluble. Aqueous solutions are acidic. |
Reactivity Profile | N-(2-Diphenylmethoxyethyl)-N,N-dimethylamine hydrochloride gives acidic solutions in water. Neutralizes bases. May react with strong oxidizing and strong reducing agents. May catalyze organic reactions. Slowly darkens on exposure to light. |
Fire Hazard | Flash point data for N-(2-Diphenylmethoxyethyl)-N,N-dimethylamine hydrochloride are not available; however, N-(2-Diphenylmethoxyethyl)-N,N-dimethylamine hydrochloride is probably combustible. |
Biological Activity | H 1 receptor antagonist. Antihistamine. |
Company Profile Introduction
Longyan Tianhua Biological Technology Co., Ltd is located in Longyan city, Fujian Province, China. It is a large-scale high-tech integrated enterprise dedicated to the research, development and sales of fine chemicals, pharmaceutical raw material intermediates, food and feed additives.
The company has its own research and development base, equipped with advanced production equipment and efficient and precise testing instruments, has set up a strict and scientific quality management system, and constantly committed to technological innovation, product innovation and management innovation, so as to ensure that our products have super competitiveness in the same industry.?
Company's main: Phenformin Hydrochloride, Chlorhexidine Acetate, Indomethacin Biphenyl benzyl azole dyclonine hydrochloride clorprenaline hydrochloride griseofulvin chloramphenicol maleic acid to guangxi pp qi, fucus xanthine tert-butyl of hydroxy anisole (BHA), ammonia, benzene pteridine zonisamide moxifloxacin mother nucleus moxifloxacin side chain moxifloxacin hydrochloride clobetasol propionate tranexamic acid raw material, and so on.?
The annual sales volume of the company is around 3 million DOLLARS. Its products have been sold to more than 40 countries and regions all over the world, and have been well received. Moreover, the buyback rate of customers is very high.
Longyan Tianhua Biotechnology Co., LTD. Is looking forward to long-term cooperation with you.
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- Since: 2019-10-11
- Address: Room 201, 11 Xinhouying Road, Xicheng Lian, Xinluo District, Longyan City, Fujian Province, China
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