10,12-Tricosadiynoic acid NEW
| Price | $41 | $66 | $91 |
| Package | 10mg | 25mg | 50mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-04-30 |
Product Details
| Product Name: 10,12-Tricosadiynoic acid | CAS No.: 66990-30-5 |
| Purity: 99.91% | Supply Ability: 10g |
| Release date: 2025/04/30 |
Product Introduction
Bioactivity
| Name | 10,12-Tricosadiynoic acid |
| Description | 10,12-Tricosadiynoic acid is a highly selective and orally active inhibitor of acyl-CoA oxidase-1 (ACOX1), which can treat high-fat diet- or obesity-induced metabolic diseases by improving mitochondrial lipid and ROS metabolism. |
| Animal Research | Animal Model: Male Wistar rats (210-230 g) fed with high-fat diet. Dosage: 100 μg/kg. Administration: Oral gavage; daily; for 8 weeks |
| In vitro | 10,12-Tricosadiynoic acid-CoA rapidly inhibits ACOX1 activity in a time- and concentration-dependent manner. The activity of ACOX1 decreases by nearly 95% after 5 min of incubation with 10 eq of 10,12-Tricosadiynoic acid-CoA. ACOX1 activity is inhibited only if free 10,12-Tricosadiynoic Acid is activated as the CoA thioester, the substrate form. The inhibition of ACOX1 by 10,12-Tricosadiynoic acid-CoA is irreversible. And the kinetics parameters KI and kinact are calculated to be 680 nm and 3.18/min, respectively. |
| In vivo | Administration of 10,12-Tricosadiynoic acid (100 μg/kg; oral gavage; daily; for 8 weeks; male Wistar rats) enhances hepatic mitochondrial fatty acid oxidation (FAO) by activating the SIRT1-AMPK pathway and proliferator activator receptor α, while reducing hydrogen peroxide accumulation in high-fat diet-fed rats, leading to significant decreases in hepatic lipid and ROS contents, body weight gain, and serum triglyceride and insulin levels. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 2.75 mg/mL (7.94 mM), Sonication is recommended. |
| Keywords | triglyceride | SIRT1-AMPK | ROS | oxidation | mono- acylglycerol acyltransferase | mitochondrial | metabolic | insulin | Inhibitor | inhibit | fatty | Diglyceride acyltransferase | Diacylglycerol acyltransferase | Acyltransferase | acyl-CoA:cholesterol acyltransferase | acyl-CoA oxidase-1 | acid | 10,12-Tricosadiynoic acid | 10,12Tricosadiynoic acid | 10,12 Tricosadiynoic acid |
| Inhibitors Related | Xanthohumol | Lecimibide | Cyclandelate | Eldacimibe | YM17E | 2-Furoic acid | Eflucimibe | Monatepil 2maleate | A 922500 | OSMI-1 | TMP-153 | PF-04620110 |
| Related Compound Libraries | Bioactive Compound Library | Anti-Obesity Compound Library | Inhibitor Library | NO PAINS Compound Library | Mitochondria-Targeted Compound Library | Orally Active Compound Library | Metabolism Compound Library | Bioactive Compounds Library Max | Covalent Inhibitor Library | Anti-Metabolism Disease Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, MA
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