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Postion:Product Catalog >Analytical Chemistry>Standard>Spectral Standards>1-(2-Thiazolylazo)-2-naphthol
1-(2-Thiazolylazo)-2-naphthol
  • 1-(2-Thiazolylazo)-2-naphthol

1-(2-Thiazolylazo)-2-naphthol

Price Get Latest Price
Package 200kg
Min. Order: 20kg
Supply Ability: 20 tons
Update Time: 2024-11-01

Product Details

Product Name: 1-(2-Thiazolylazo)-2-naphthol CAS No.: 1147-56-4
Min. Order: 20kg Purity: 99%
Supply Ability: 20 tons Release date: 2024/11/01

1147-56-4 - Physico-chemical Properties

Molecular FormulaC13H9N3OS
Molar Mass255.3
Density1.40
Melting Point138-139°C
Boling Point464.8±47.0 °C(Predicted)
Flash Point270.253°C
Solubilitymethanol: 10mg/mL, clear
Vapor Presure0mmHg at 25°C
Appearancesolid
ColorRed or orange
BRN223783
pKa8.71±0.50(Predicted)
Storage Condition2-8°C
StabilityStable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Refractive Index1.728
MDLMFCD00021611
In vitro studyNSC139021 selectively inhibits growth of ERGpositive cancer cell lines with minimal effect on normal prostate or endothelial cells or ERG-negative tumor cell lines. The IC 50 of NSC139021 for cell growth inhibition of responsive cell lines range between 30 nM to 400 nM. Combination of NSC139021 with enzalutamide shows additive effects in inhibiting growth of VCaP cells. A screen of kinases reveal that NSC139021 directly bound the ribosomal biogenesis regulator atypical kinase RIOK2 and induces ribosomal stress signature.
In vivo studyNSC139021 treatment inhibits growth of ERG-positive VCaP tumor xenografts with no apparent toxicity. Significant (P<0.05, P<0.005) inhibition of tumor growth is noted at day 26 in treatment groups indicating 44% (100 mg/kg) and 65% (150 mg/kg) reduction of tumor burden. At 100 mg/kg and 150 mg/kg, no apparent toxicity including weight loss, lethargy, diarrhea, loss of appetite, respiratory distress, or overall drug related toxicity is observed. .


Company Profile Introduction

Qingdao RENAS Polymer Material Co., Ltd. is located in E.T.D.Z of Qingdao China, it is one integrated company, devoted to environmental protection and low carbon energy, new materials introducing, research and development, which aims to offer the best quality products and service to the domestic and foreign markets. We maintain a good partnership with many word famous chemical manufacturers. Integrated of advanced products and technology of domestic and foreign manufacturers, we could customize the products matching scheme for various industries customers, and offer the comprehensive solution to customers. We have unique technology and product advantages, especial in the field of rubber additive, acrylic monomer, solvent, pharmaceutical intermediates and ink coating resin. We have a professional management, business and technical team, and have passed the ISO9001 system certification. We have passed the fast response ability and reliable product quality. With the mission of "steady development and dedication to China", we adhere to the business philosophy of "the interests of users are our most fundamental interests, and the needs of users are our needs". Through concept innovation, management innovation, technical innovation, market innovation, and product innovation, Strive to make the company an excellent supplier in the field of global chemical materials. We welcome friends all over the world to visit and negotiate with us. We sincerely hope to expand our trade and cooperation based on mutual benefits and realize the mutual prosperity and development.

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