4-OXO-1,4-DIHYDRO-[1,10]PHENANTHROLINE-3-CARBOXYLIC ACID
| 中文名稱 | 4-OXO-1,4-DIHYDRO-[1,10]PHENANTHROLINE-3-CARBOXYLIC ACID |
|---|---|
| 中文同義詞 | 4-氧代-1,4-二氫-[1,10]鄰二氮雜菲-3-羧酸;化合物1,4-DPCA;1,4-DPCA化學(xué)試劑;4-氧代-4,4-二氫-1,10-菲咯啉-3-羧酸;化合物1,4-DPCA,10 MM DMSO 溶液 |
| 英文名稱 | 4-OXO-1,4-DIHYDRO-[1,10]PHENANTHROLINE-3-CARBOXYLIC ACID |
| 英文同義詞 | 4-OXO-1,4-DIHYDRO-[1,10]PHENANTHROLINE-3-CARBOXYLIC ACID;1,4-DPCA;TVBAVFFTADCWKG-UHFFFAOYSA-N;4-DPCA;HIF-PH,HIF/HIF Prolyl-Hydroxylase,HIF-1α,HIFs,FIH,P4HA1,P4HA2,1,4DPCA,healing,Inhibitor,Hypoxia-inducible factors,1,4 DPCA,wound,inhibit,1,4-DPCA,P4HA3;1,10-Phenanthroline-3-carboxylic acid, 4,4a-dihydro-4-oxo-;4-Oxo-4,4a-dihydro-1,10-phenanthroline-3-carboxylic acid;1,4-DPCA, 10 mM in DMSO |
| CAS號 | 331830-20-7 |
| 分子式 | C13H8N2O3 |
| 分子量 | 240.21 |
| EINECS號 | |
| 相關(guān)類別 | |
| Mol文件 | 331830-20-7.mol |
| 結(jié)構(gòu)式 | ![4-OXO-1,4-DIHYDRO-[1,10]PHENANTHROLINE-3-CARBOXYLIC ACID 結(jié)構(gòu)式](CAS/GIF/331830-20-7.gif) |
4-OXO-1,4-DIHYDRO-[1,10]PHENANTHROLINE-3-CARBOXYLIC ACID 性質(zhì)
| 沸點 | 419.5±45.0 °C(Predicted) |
|---|---|
| 密度 | 1.52±0.1 g/cm3(Predicted) |
| 儲存條件 | RT |
| 溶解度 | 可溶于 DMSO（升溫時高達(dá) 15 mg/ml）。 |
| 形態(tài) | 棕褐色固體。 |
| 酸度系數(shù)(pKa) | 2.55±0.20(Predicted) |
| 顏色 | 米白色 |
| 穩(wěn)定性 | 可在-20°下的DMSO中的溶液保存長達(dá)2個月。 |
IC50: 2.4 μM (Collagen hydroxylation); 60 μM (Factor inhibiting HIF (FIH))
1,4-DPCA (24 hours) treatment specifically increases the expression of multiple target genes, including the proangiogenic target genes Vegfa and Hmox1 and proglycolytic targets Ldh-a, Pgk1, Pdk1, and Glut1 in mouse B6 cells.
1,4-DPCA treatment significantly reduces the colony sizes of T4-2 (10 μM 1,4-DPCA) and ZR-75-1 cells (20 μM 1,4-DPCA). 1,4-DPCA-treated T4-2 cells form polarized spheroids in 3D culture. 1,4-DPCA treatment significantly reduces invasive branches in DA-MB-157 (20 μM 1,4-DPCA) and MDA-MB-231 (10 μM 1,4-DPCA) cells.1,4-DPCA inhibits the proliferation of T4-2, ZR-75-1, MDA-MB-157 and MDA-MB-231 cells.
1,4-DPCA treatment suppresses connective tissue ingrowth in porous porous poly (lactic-co-glycolic acid) (PLGA) discs implanted in the peritoneal cavity for 28 days in mice. 1,4-DPCA is found to be effective at inhibiting collagen deposition within and on the outer surface of the disc, and also limited connective tissue ingrowth, but not to the extent of glucocorticoid inhibition.
安全信息
| 更新日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
|---|---|---|---|---|---|
| 2024/11/08 | HY-121172 | 4-OXO-1,4-DIHYDRO-[1,10]PHENANTHROLINE-3-CARBOXYLIC ACID 1,4-DPCA | 331830-20-7 | 5mg | 600元 |
| 2024/11/08 | HY-121172 | 4-OXO-1,4-DIHYDRO-[1,10]PHENANTHROLINE-3-CARBOXYLIC ACID 1,4-DPCA | 331830-20-7 | 10mM * 1mLin DMSO | 660元 |