205654-37-1
中文名稱 | 205654-37-1 |
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中文同義詞 | 化合物 T10844;化合物 CMI-392 |
英文名稱 | Urea, N'-[[2-[2-[(4-chlorophenyl)thio]ethoxy]-3-methoxy-5-[(2S,5S)-tetrahydro-5-(3,4,5-trimethoxyphenyl)-2-furanyl]phenyl]methyl]-N-hydroxy-N-methyl- |
英文同義詞 | Urea, N'-[[2-[2-[(4-chlorophenyl)thio]ethoxy]-3-methoxy-5-[(2S,5S)-tetrahydro-5-(3,4,5-trimethoxyphenyl)-2-furanyl]phenyl]methyl]-N-hydroxy-N-methyl-;CMI 392,CMI392 |
CAS號 | 205654-37-1 |
分子式 | C31H37ClN2O8S |
分子量 | 633.15 |
EINECS號 | |
相關(guān)類別 | |
Mol文件 | 205654-37-1.mol |
結(jié)構(gòu)式 | ![]() |
205654-37-1 性質(zhì)
密度 | 1.35±0.1 g/cm3(Predicted) |
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儲存條件 | Store at -20°C |
溶解度 | 溶于二甲基亞砜 |
酸度系數(shù)(pKa) | 9.82±0.50(Predicted) |
5-LO 100 nM (IC 50 ) |
PAF 10 nM (IC 50 ) |
Topical treatment of CMI-392 in the acute and chronic TPA models result in a significant decrease of ear weight, inflammatory cell infiltration, and histological examination. The ED 50 for PAF-induced mouse hemoconcentration and arachidonic acid-induced mouse ear edema are 2.2 and 1.8 mg/kg, respectively.