200803-37-8
| 中文名稱 | 200803-37-8 |
|---|---|
| 中文同義詞 | 化合物 T13807;化合物 OSIP-486823 |
| 英文名稱 | OSIP-486823 |
| 英文同義詞 | OSIP-486823;CP248;1H-Indene-3-acetamide, 5-fluoro-2-methyl-N-(phenylmethyl)-1-[(3,4,5-trimethoxyphenyl)methylene]-, (1Z)-;OSIP486823,OSIP 486823 |
| CAS號 | 200803-37-8 |
| 分子式 | C29H28FNO4 |
| 分子量 | 473.54 |
| EINECS號 | |
| 相關(guān)類別 | |
| Mol文件 | 200803-37-8.mol |
| 結(jié)構(gòu)式 |  |
200803-37-8 性質(zhì)
| 沸點 | 667.3±55.0 °C(Predicted) |
|---|---|
| 密度 | 1.206±0.06 g/cm3(Predicted) |
| 儲存條件 | Store at -20°C |
| 溶解度 | 溶于二甲基亞砜 |
| 形態(tài) | 固體 |
| 酸度系數(shù)(pKa) | 15.72±0.46(Predicted) |
| 顏色 | 淺黃至黃色 |
OSIP-486823 是一種新型的微管干擾劑，對蛋白激酶 G (PKG) 和微管均具有生物學(xué)作用。
Microtubule
OSIP486823 inhibits growth and induce apoptosis in SW480 human colon cancer cells, with IC 50 of 0.1 μM. OSIP-486823 (OSIP486823) causes depolymerization of microtubules in interphase cells, inhibit spindle formation in mitotic cells, and induce multinucleated cells. Exisulind and the potent synthetic derivative OSIP-486823 are members of a new class of drugs known as selective apoptotic antineoplastic drugs that target cyclic guanosine 3′,5′-monophosphate phosphodiesterases (cGMP-PDE). OSIP-486823 also disrupts microtubule polymerization, perturbs mitotic spindle function, and arrests cells in mitosis in human glioma cells.
安全信息
| 更新日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
|---|---|---|---|---|---|
| 2025/02/08 | HY-U00004 | OSIP-486823 | 200803-37-8 | 1 mg | 5800元 |
| 2023/03/20 | HY-U00004 | 200803-37-8 OSIP-486823 | 200803-37-8 | 5mg | 14500元 |