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| (2'Z,3'E)-6-BROMOINDIRUBIN-3'-ACETOXIME Basic information |
| (2'Z,3'E)-6-BROMOINDIRUBIN-3'-ACETOXIME Chemical Properties |
density | 1.69±0.1 g/cm3(Predicted) | storage temp. | Keep in dark place,Sealed in dry,2-8°C | solubility | H2O: soluble2mg/mL (clear solution, warmed) | form | powder | pka | 9.22±0.20(Predicted) | color | dark red to purple | Water Solubility | H2O: 2mg/mL (clear solution, warmed) |
Hazard Codes | Xn,N | Risk Statements | 22-50/53 | Safety Statements | 60-61 | RIDADR | UN 3077 9 / PGIII | WGK Germany | 3 |
| (2'Z,3'E)-6-BROMOINDIRUBIN-3'-ACETOXIME Usage And Synthesis |
Uses | BIO-Acetoxime is a potent and selective GSK-3a/b inhibitor that reduces invasiveness of gliomas and extends animal survival in intracranial glioma models. It also induces Wnt signaling and inhibits CD8+ T cell effector differentiation. | Biological Activity | Selective GSK-3 α / β inhibitor (IC 50 values are 0.01, 2.4, 4.3 and 63 μ M for GSK-3 α / β , CDK5/p25, CDK2/cyclin A and CDK1/cyclin B respectively). Induces Wnt signaling and inhibits CD8+ T cell effector differentiation. | storage | Store at +4°C |
| (2'Z,3'E)-6-BROMOINDIRUBIN-3'-ACETOXIME Preparation Products And Raw materials |
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