6RK73
| 中文名稱 | 6RK73 |
|---|---|
| 中文同義詞 | 化合物 T10188;化合物6RK73;化合物6RK73,10 MM DMSO 溶液 |
| 英文名稱 | 6RK73 |
| 英文同義詞 | 6RK73;6RK-73,6RK73;3-Pyrrolidinecarboxamide, 1-cyano-N-[5-(4-morpholinyl)-2-thiazolyl]-, (3S)-;6RK73, 10 mM in DMSO |
| CAS號 | 1895050-66-4 |
| 分子式 | C13H17N5O2S |
| 分子量 | 307.37 |
| EINECS號 | |
| 相關(guān)類別 | 制劑-抑制劑 |
| Mol文件 | 1895050-66-4.mol |
| 結(jié)構(gòu)式 |  |
6RK73 性質(zhì)
| 密度 | 1.41±0.1 g/cm3(Predicted) |
|---|---|
| 儲存條件 | Store at -20°C |
| 溶解度 | 溶于二甲基亞砜 |
| 形態(tài) | 固體 |
| 酸度系數(shù)(pKa) | 8.04±0.70(Predicted) |
| 顏色 | 米白色至淺黃色 |
6RK73 是一種共價不可逆的特異性 UCHL1 抑制劑，IC50 為 0.23 μM。6RK73 對 UCHL3 幾乎沒有抑制效果 (IC50=236 μM)。6RK73 特異性抑制乳腺癌中 UCHL1 的活性。
IC50: 0.23 μM (UCHL1), 236 μM (UCHL3)
6RK73 (5 μM; 1-3 hours) treatment displays strong inhibition of the TGFβ-induced pSMAD2 and pSMAD3, and a decrease of TβRI and total SMAD protein levels in MDA-MB-436 cells.
6RK73(5 μM; 24-48 hours) results migration significantly slower than the DMSO control group in MDA-MB-436 cells.
Cell Viability Assay
| Cell Line: | MDA-MB-436 cells |
| Concentration: | 5 μM |
| Incubation Time: | 24, 48 hours |
| Result: | Migrated significantly slower than the DMSO control group |
Western Blot Analysis
| Cell Line: | MDA-MB-436 cells |
| Concentration: | 5 μM |
| Incubation Time: | 1, 2, 3 hours |
| Result: | Displayed strong inhibition of the TGFβ-induced pSMAD2 and pSMAD3, and a decrease of TβRI and total SMAD protein levels. |
6RK73 displays a potent inhibition of breast cancer extravasation in zebrafish.
安全信息
| 更新日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
|---|---|---|---|---|---|
| 2025/02/05 | HY-133118 | 6RK73 | 1895050-66-4 | 1 mg | 1447元 |
| 2025/02/05 | HY-133118 | 6RK73 6RK73 | 1895050-66-4 | 10mM * 1mLin DMSO | 2570元 |