106362-32-7
| 中文名稱 | 106362-32-7 |
|---|---|
| 中文同義詞 | 多肽T H-ALA-SER-THR-THR-THR-ASN-TYR-THR-OH;肽T;PEPTIDE T;ASTTTNYT;多肽T;T肽;Peptide T多肽;L-丙氨酰-L-絲氨酰-L-蘇氨酰-L-蘇氨酰-L-蘇氨酰-L-天冬氨酰-L-酪氨酰-L-蘇氨酸 |
| 英文名稱 | ALA-SER-THR-THR-THR-ASN-TYR-THR ACETATE |
| 英文同義詞 | ALA-SER-THR-THR-THR-ASN-TYR-THR ACETATE;L-Threonine, L-alanyl-L-seryl-L-threonyl-L-threonyl-L-threonyl-L-asparaginyl-L-tyrosyl-;L-Threonine, N-(N-(N2-(N-(N-(N-(N-L-alanyl-L-seryl)-L-thronyl)-L-threonyl)-L-threonyl)-L-asparaginyl)-L-tyrosyl)-;Ala-Ser-Thr-Thr-Thr-Asn-Tyr-Thr acetate salt |
| CAS號(hào) | 106362-32-7 |
| 分子式 | C35H55N9O16 |
| 分子量 | 857.86 |
| EINECS號(hào) | |
| 相關(guān)類別 | 目錄多肽 |
| Mol文件 | 106362-32-7.mol |
| 結(jié)構(gòu)式 |  |
106362-32-7 性質(zhì)
| 沸點(diǎn) | 1499.5±65.0 °C(Predicted) |
|---|---|
| 密度 | 1.432±0.06 g/cm3(Predicted) |
| 儲(chǔ)存條件 | -20°C |
| 溶解度 | 溶于二甲基亞砜 |
| 酸度系數(shù)(pKa) | 3.21±0.10(Predicted) |
| 形態(tài) | 固體 |
| 顏色 | 白色至米白色 |
| 序列 | Ala-Ser-Thr-Thr-Thr-Asn-Tyr-Thr |
Peptide T是源自HIV-1 gp120的V2區(qū)的八肽。 Peptide T是 CD4 受體的配體，可阻止 HIV 與CD4受體結(jié)合。
CD4, HIV
Peptide T acts to block viral entry as it inhibits in the MAGI cell assay and blocks infection in the luciferase reporter assay using HIV virions pseudotyped with ADA envelope. Peptide T selectively inhibits HIV replication using chemokine receptor CCR5 compared to CXC4. Peptide T at 10 -8 M induces IL-10 production by the human Th2 cell line and PBMC. Also peptide T at 10 -9 M concentration significantly inhibits IFN-g production by PBMC.
Peptide T is administered subcutaneously at different doses and phases of the experimental autoimmune encephalomyelitis (EAE) disease, but Peptide T neither prevents nor ameliorates EAE.