| Company Name: |
BOC Sciences
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1-631-485-4226; 16314854226 |
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info@bocsci.com |
| Products Intro: |
Product Name:(S)-Mapracorat
CAS:887375-15-7
Purity:>=95% Remarks:Reach out to us for more information about custom solutions.
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| Company Name: |
DC Chemicals
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| Tel: |
021-58447131 13564518121 |
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sales@dcchemicals.com |
| Products Intro: |
Product Name:(S)-Mapracorat
CAS:887375-15-7
Purity:98% HPLC Package:100mg，250mg，1g
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| Company Name: |
Changzhou Xuanye Technology Co., Ltd
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| Tel: |
15195022192 |
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279776773@qq.com |
| Products Intro: |
Product Name:(S)-Mapracorat
CAS:887375-15-7
Purity:97 Package:1g,5g,10g,25g,50g 500 g ,1 kg.5 kg
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| | (S)-BOL-303242X) Basic information |
| Product Name: | (S)-BOL-303242X) | | Synonyms: | (S)-BOL-303242X);(S)-Mapracorat (Synonyms: (S)-ZK-245186;(Synonyms: (S)-ZK-245186;(SYNONYMS: (S)-ZK-245186; (S)-BOL-303242X);(S)-Mapracorat;(S)-ZK-245186;7-Benzofuranpropanol, 5-fluoro-2,3-dihydro-γ,γ-dimethyl-α-[[(2-methyl-5-quinolinyl)amino]methyl]-α-(trifluoromethyl)-, (αS)- | | CAS: | 887375-15-7 | | MF: | C25H26F4N2O2 | | MW: | 462.49 | | EINECS: | | | Product Categories: | | | Mol File: | 887375-15-7.mol |  |
| | (S)-BOL-303242X) Chemical Properties |
| Boiling point | 602.1±55.0 °C(Predicted) | | density | 1.316±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO: ≥ 50.6 mg/mL (109.41 mM) | | pka | 11.75±0.29(Predicted) | | form | Solid | | color | Light yellow to yellow |
| | (S)-BOL-303242X) Usage And Synthesis |
| Description | (S)-Mapracorat is a selective and less active glucocorticoid receptor agonist.
(S)-Mapracorat concentration dependently inhibited TNFα secretion from activated canine PBMC with IC50 value of approximately 0.2 nM. Intradermal injection of compound 48/80 (50 μg in 50 μL saline) resulted in a clear wheal and flare reaction over the 60 min observation period. Topical pre-treatment with (S)-Mapracorat (0.1%) leads to significant reduction in the wheal and flare responses compared to vehicle (acetone) treated areas. | | Uses | (S)-Mapracorat is a selective and less active glucocorticoid receptor agonist. | | in vivo | Intradermal injection of compound 48/80 (50 μg in 50 μL saline) resulted in a clear wheal and flare reaction over the 60 min observation period. Topical pre-treatment with (S)-Mapracorat (0.1%) leads to significant reduction in the wheal and flare responses compared to vehicle (acetone) treated areas. | | References | [1]. BÄumer W , et al. The selective glucocorticoid receptor agonist mapracorat displays a favourable safety-efficacy ratio for the topical treatment of inflammatory skin diseases in dogs. Vet Dermatol. 2017 Feb; 28(1):46-e11. |
| | (S)-BOL-303242X) Preparation Products And Raw materials |
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