| Company Name: |
BOC Sciences
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| Tel: |
1-631-485-4226; 16314854226 |
| Email: |
info@bocsci.com |
| Products Intro: |
Product Name:CAY10608
CAS:457897-92-6
Purity:>=98% Remarks:Reach out to us for more information about custom solutions.
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| Company Name: |
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
|
| Tel: |
18818260767 |
| Email: |
sales@chemegen.com |
| Products Intro: |
Product Name:CAY10608
CAS:457897-92-6
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
|
| Company Name: |
TargetMol Chemicals Inc.
|
| Tel: |
4008200310 |
| Email: |
marketing@tsbiochem.com |
| Products Intro: |
Product Name:CAY10608
CAS:457897-92-6
Package:1mg/RMB 665;5mg/RMB 2900;10mg/RMB 4970
|
CAY10608 manufacturers
- CAY10608
-
- $95.00 / 1mg
-
2024-10-28
- CAS:457897-92-6
- Min. Order:
- Purity:
- Supply Ability: 10g
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| | CAY10608 Basic information |
| Product Name: | CAY10608 | | Synonyms: | CAY10608;N-[4-[(2S)-3-[[2-(3,4-dichlorophenyl)ethyl]amino]-2-hydroxypropoxy]phenyl]-methanesulfonamide;CAY10608 Exclusive;Methanesulfonamide, N-[4-[(2S)-3-[[2-(3,4-dichlorophenyl)ethyl]amino]-2-hydroxypropoxy]phenyl]- | | CAS: | 457897-92-6 | | MF: | C18H22Cl2N2O4S | | MW: | 433.35 | | EINECS: | | | Product Categories: | | | Mol File: | 457897-92-6.mol |  |
| | CAY10608 Chemical Properties |
| Boiling point | 611.8±65.0 °C(Predicted) | | density | 1.392±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMF: 12.5 mg/ml; DMSO: 14 mg/ml; DMSO:PBS (pH 7.2) (1:10): 0.1 mg/ml | | form | A crystalline solid | | pka | 8.81±0.10(Predicted) |
| | CAY10608 Usage And Synthesis |
| Description | N-Methyl-D-aspartate (NMDA) receptors are Ca2+ permeable ligand-gated channels of the central nervous system that are activated after binding of the co-agonists glutamate and glycine. CAY10608 is a propanolamine that potently, selectively, and non-competitively antagonizes the NR2B subunit of NMDA receptors (IC50 = 50 nM).1 It does not inhibit NR1, NR2A, NR2C, and NR2D subunits and has no significant effects on α-amino-3-hydroxy-5-methyl-4-isoxazolepropioinic acid (AMPA) or kainate receptors.1 CAY10608 is neuroprotective, since it prevents NMDA-triggered release of lactate dehydrogenase from cultured cortical neurons. Also, CAY10608, when administered intraperitoneally, reduces brain infarct volume resulting from transient ischemia via carotid artery occlusion.1 | | Uses | NR2B-selective NMDA receptor antagonist 1 (compound 29) is a potent antagonist of NR1/NR2B receptors, with IC50s of 0.05 μM, 0.73 μM, 2.4 μM to NR1/NR2B NMDA receptor, hERG, α1-AdR, respectivity. NR2B-selective NMDA receptor antagonist 1 exhibites efficient permeability across the blood–brain barrier[1]. | | in vivo | NR2B-selective NMDA receptor antagonist 1 (compound 29) (30 mg/kg, i.p. once) shows reduction of infarct volume[1]. | | References | 1. Tahirovic, Y.A., Geballe, M., Gruszecka-Kowalik, E., et al. Enantiomeric propanolamines as selective N-methyl-D-aspartate 2B receptor antagonists J. Med. Chem. 51,5506-5521(2008). |
| | CAY10608 Preparation Products And Raw materials |
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