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1-(4-Fluorophenyl)-N-[3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]-1,2-dihydro-2-oxo-3-pyridinecarboxamide

1-(4-Fluorophenyl)-N-[3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]-1,2-dihydro-2-oxo-3-pyridinecarboxamide Suppliers list
Company Name: ATK CHEMICAL COMPANY LIMITED
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Products Intro: Product Name:BMS-2
CAS:888719-03-7
Purity:98% Package:5MG;10MG;50MG;100MG,1G,5G
Company Name: CONIER CHEM AND PHARMA LIMITED
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Products Intro: Product Name:1-(4-fluorophenyl)-n-(3-fluoro-4-(1h-pyrrolo(2,3-b)pyridin-4-yloxy)phenyl)-1,2-dihydro-2-oxo-3-pyridinecarboxamide
CAS:888719-03-7
Purity:0.99 Package:1kg
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Products Intro: Product Name:1-(4-Fluorophenyl)-N-[3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]-1,2-dihydro-2-oxo-3-pyridinecarboxamide
CAS:888719-03-7
Purity:Above 98% Summer 618 Package:1g;9USD
Company Name: InvivoChem
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Products Intro: Product Name:BMS-2
CAS:888719-03-7
Purity:98% Package:5mg Remarks:V7744
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Products Intro: Product Name:1-(4-Fluorophenyl)-N-[3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]-1,2-dihydro-2-oxo-3-pyridinecarboxamide
CAS:888719-03-7
Package:1g; 5g; 25g; 1kg; 5kg; 25kg
1-(4-Fluorophenyl)-N-[3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]-1,2-dihydro-2-oxo-3-pyridinecarboxamide Basic information
Product Name:1-(4-Fluorophenyl)-N-[3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]-1,2-dihydro-2-oxo-3-pyridinecarboxamide
Synonyms:1-(4-Fluorophenyl)-N-[3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]-1,2-dihydro-2-oxo-3-pyridinecarboxamide;BMS-2;BMS-21-(4-Fluorophenyl)-N-[3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]-1,2-dihydro-2-oxo-3-pyridinecarboxamide;N-(4-((1H-Pyrrolo[2,3-b]pyridin-4-yl)oxy)-3-fluorophenyl)-1-(4-fluorophenyl)-2-oxo-1,2-dihydro;3-Pyridinecarboxamide, 1-(4-fluorophenyl)-N-[3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]-1,2-dihydro-2-oxo-;BMS2;BMS 2;N-(4-(1H-PYRROLO[2,3-B]PYRIDIN-4-YLOXY)-3-FLUOROPHENYL)-1-(4-FLUOROPHENYL)-2-OXO-1,2-DIHYDROPYRIDINE-3-CARBOXAMIDE;SYN-1022
CAS:888719-03-7
MF:C25H16F2N4O3
MW:458.42
EINECS:
Product Categories:
Mol File:888719-03-7.mol
1-(4-Fluorophenyl)-N-[3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]-1,2-dihydro-2-oxo-3-pyridinecarboxamide Structure
1-(4-Fluorophenyl)-N-[3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]-1,2-dihydro-2-oxo-3-pyridinecarboxamide Chemical Properties
Melting point 212-214℃
density 1.41
storage temp. 2-8°C
solubility ethanol: 1mg/mL
DMSO: 10mg/mL
form Solid
pka10.72±0.70(Predicted)
color Off-white to light yellow
Safety Information
MSDS Information
1-(4-Fluorophenyl)-N-[3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]-1,2-dihydro-2-oxo-3-pyridinecarboxamide Usage And Synthesis
UsesBMS-2 is a potent MET kinase inhibitor.
in vivo

MET kinase-IN-4 (Compound 2) (i.v., p.o.; 5, 10 mg/kg) possesses a favorable pharmacokinetic profile in mice[1].
MET kinase-IN-4 (p.o.; 6.25, 12.5, 25 and 50 mg/kg; once a day) demonstrates significant in vivo antitumor activity in the GTL-16 human gastric carcinoma xenograft model[1].

Animal Model:Mice[1]
Dosage:5, 10 mg/kg
Administration:IV, PO
Result:Showed extensive extravascular distribution and a favorable half-life.
Animal Model:Nude mice[1]
Dosage:6.25, 12.5, 25 and 50 mg/kg
Administration:PO, once a day
Result:Showed antitumor activity in dose-dependet.
1-(4-Fluorophenyl)-N-[3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]-1,2-dihydro-2-oxo-3-pyridinecarboxamide Preparation Products And Raw materials
Tag:1-(4-Fluorophenyl)-N-[3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]-1,2-dihydro-2-oxo-3-pyridinecarboxamide(888719-03-7) Related Product Information
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