LE 135
| 中文名稱 | LE 135 |
|---|---|
| 中文同義詞 | 化合物 T22920;化合物L(fēng)E135;4-(5,7,7,10,10-五甲基-7,8,9,10-四氫-5H-苯并[E]萘并[2,3-B][1,4]二氮雜卓-13-基)苯甲酸;LE 135,RARΒ拮抗劑;化合物L(fēng)E135,10 MM DMSO 溶液 |
| 英文名稱 | 4-(7,8,9,10-TETRAHYDRO-5,7,7,10,10-PENTAMETHYL-5H-BENZO[E]NAPHTHO[2,3-B][1,4]DIAZEPIN-13-YL)BENZOIC ACID |
| 英文同義詞 | 4-(7,8,9,10-TETRAHYDRO-5,7,7,10,10-PENTAMETHYL-5H-BENZO[E]NAPHTHO[2,3-B][1,4]DIAZEPIN-13-YL)BENZOIC ACID;LE 135;4-(7,8,9,10-Tetrahydro-5,7,7,10,10-pentamethyl-(5H)-benzo[e]naphtho[2.3-b][1.4]diazepine-13-yl)benzoicacid;Benzoic acid, 4-(7,8,9,10-tetrahydro-5,7,7,10,10-pentaMethyl-5H-benzo[e]naphtho[2,3-b][1,4]diazepin-13-yl)-;4-(5,7,7,10,10-Pentamethyl-7,8,9,10-tetrahydro-5H-benzo[e]naphtho[2,3-b][1,4]diazepin-13-yl)benzoic acid;4-(7,8,9,10-Tetrahydro-5,7,7,10,10-pentamethyl-5H-benzo[e]naphtho[2,3-b][1,4]diazepin-13-yl)benzoic acid;LE135, 10 mM in DMSO |
| CAS號(hào) | 155877-83-1 |
| 分子式 | C29H30N2O2 |
| 分子量 | 438.56 |
| EINECS號(hào) | |
| 相關(guān)類別 | Intracellular receptor |
| Mol文件 | 155877-83-1.mol |
| 結(jié)構(gòu)式 |  |
LE 135 性質(zhì)
| 沸點(diǎn) | 601.3±55.0 °C(Predicted) |
|---|---|
| 密度 | 1.17±0.1 g/cm3(Predicted) |
| 儲(chǔ)存條件 | 2-8°C |
| 溶解度 | DMSO：可溶15mg/mL，澄清 |
| 酸度系數(shù)(pKa) | 3.02±0.10(Predicted) |
| 形態(tài) | 粉末 |
| 顏色 | 黃色至橙色粘性至蠟狀 |
|
RARβ 220 nM (Ki) |
RARα 1400 nM (Ki) |
TRPV1 2.5 μM (EC 50 ) |
TRPA1 20 μM (EC 50 ) |
LE135 inhibits Am80-induced differentiation of human promyelocytic leukemia cells HL-60 with an IC
50
of 150 nM.
LE135 inhibits retinoic acid (RA)-induced transcriptional activation of RARβ, but not RARα, RARγ or retinoid X receptor α (RXRα), on a variety of RA response elements. LE135 strongly represses 12-O-tetradecanoylphorbol-13-acetate-induced AP-1 activity in the presence of RARβ and RXRα.
LE135 provokes nociceptive responses and elicited thermal hyperalgesia mainly through TRPV1 channels, but required both TRPA1 and TRPV1 channels for producing mechanical allodynia. Intraplantar injection of LE135 (30?nmol/10?μL) induces mechanical hypersensitivity in wild-type and Trpa1 ?/? mice.
| 更新日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
|---|---|---|---|---|---|
| 2025/02/05 | HY-107436 | LE135 | 155877-83-1 | 1 mg | 480元 |
| 2025/02/05 | HY-107436 | LE 135 LE135 | 155877-83-1 | 5mg | 1200元 |