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格拉非寧 鹽酸鹽

格拉非寧 鹽酸鹽

中文名稱格拉非寧 鹽酸鹽
中文同義詞格拉非寧 鹽酸鹽;2,3-二羥基丙基2-((7-氯喹啉-4-基)氨基)苯甲酸酯鹽酸鹽;鹽酸格拉芬寧
英文名稱1-GLYCERYL N-[7-CHLORO-4-QUINOLYL]ANTHRANILATE HYDROCHLORIDE
英文同義詞GlafenineHCl;Glafenin hydrochloride;GLAFENINE HYDROCHLORIDE;1-GLYCERYL N-[7-CHLORO-4-QUINOLYL]ANTHRANILATE HYDROCHLORIDE;2,3-Dihydroxypropyl 2-((7-chloroquinolin-4-yl)amino)benzoate hydrochloride;inhibit,Glafenine Hydrochloride,Glafenine,Glafenin,Inhibitor
CAS號(hào)65513-72-6
分子式C19H18Cl2N2O4
分子量409.26
EINECS號(hào)
相關(guān)類別小分子抑制劑
Mol文件65513-72-6.mol
結(jié)構(gòu)式格拉非寧 鹽酸鹽 結(jié)構(gòu)式

格拉非寧 鹽酸鹽 性質(zhì)

儲(chǔ)存條件Inert atmosphere,Room Temperature
溶解度二甲基亞砜:≥ 60 mg/mL(146.61 mM)
形態(tài)固體
顏色淺黃至黃色

格拉非寧 鹽酸鹽 用途與合成方法

Glafenine hydrochloride 是一種非甾體抗炎藥 (NSAID), 具有鎮(zhèn)痛活性。

IC50: 3.2 μM (ABCG2)

Glafenine increases the surface expressionof mutant CFTR in baby hamster kidney (BHK) cells to 40% of that observed for wild-type CFTR. Glafenine hydrochloride inhibits the proliferation and clonogenic activity of haSMCs and ECs in a dose-dependent manner. A block in the G2/M phase and a reduction in the G1 phase occurr. The migratory ability of haSMCs is impaired in a dose-dependent manner and the extracellular matrix protein tenascin is reduced.

Glafenine injection (25 mg/kg i.v.) shows enhanced BLI signal in mice with an average of 2.9-fold signal enhancement over the control. Glafenine causes increases in BLI signal of up to 11.6- and 17.4-fold in two separate HEK293/ABCG2/fLuc xenografts in the same mouse compared to the signals generated by those xenografts immediately before injection. Incubating polarized CFBE41o - monolayers and intestines isolated from mutant CFTR mice with glafenine increases the short-circuit current response to forskolin and genistein. Treatment with glafenine also partially restores total salivary secretion. Glafenine-treated zebrafish shows evidence of endoplasmic reticulum and mitochondrial stress, with disrupted intestinal architecture and halted cell stress responses, alongside accumulation of apoptotic intestinal epithelial cells in the lumen.

安全信息

危險(xiǎn)品標(biāo)志Xn
危險(xiǎn)類別碼22
安全說明36
WGK Germany3
RTECS號(hào)CB2687000

MSDS信息

提供商 語言
英文

格拉非寧 鹽酸鹽 上下游產(chǎn)品信息

"格拉非寧 鹽酸鹽"相關(guān)產(chǎn)品信息
吡啶鹽酸鹽 三甲胺鹽酸鹽 三乙胺鹽酸鹽 甲胺鹽酸鹽 鹽酸安非拉酮
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