Mal-?PEG4-?propargyl manufacturers
- Mal-PEG4-propargyl
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- $0.00 / 1g
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2025-06-07
- CAS:1262681-30-0
- Min. Order: 1g
- Purity: >98.00%
- Supply Ability: 1g
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| | Mal-?PEG4-?propargyl Basic information |
| Product Name: | Mal-?PEG4-?propargyl | | Synonyms: | Mal-?PEG4-?propargyl;Propargyl-PEG4-Mal;1H-Pyrrole-2,5-dione, 1-(3,6,9,12-tetraoxapentadec-14-yn-1-yl)-;1-[2-[2-[2-(2-prop-2-ynoxyethoxy)ethoxy]ethoxy]ethyl]pyrrole-2,5-dione;1-(3,6,9,12-tetraoxapentadec-14-yn-1-yl)-2,5-dihydro-1H-pyrrole-2,5-dione;1-(3,6,9,12-Tetraoxapentadec-14-yn-1-yl)-1H-pyrrole-2,5-dione | | CAS: | 1262681-30-0 | | MF: | C15H21NO6 | | MW: | 311.33 | | EINECS: | | | Product Categories: | | | Mol File: | 1262681-30-0.mol |  |
| | Mal-?PEG4-?propargyl Chemical Properties |
| Boiling point | 432.0±40.0 °C(Predicted) | | density | 1.190±0.06 g/cm3(Predicted) | | solubility | good in water, DMF, DMSO | | form | Oil | | pka | -2.34±0.20(Predicted) | | color | Colorless to light yellow |
| | Mal-?PEG4-?propargyl Usage And Synthesis |
| Description | Propargyl-PEG4-Maleimide has a propargyl group and a maleimide group. The propargyl group reacts with azide compounds or biomolecules under the catalyzation of copper in Click Chemistry reactions. The maleimide group enables the formation of a covalent bond with biomolecules containing a thiol group. | | Uses | Mal-PEG4-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Mal-PEG4-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | | IC 50 | PEGs | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
| | Mal-?PEG4-?propargyl Preparation Products And Raw materials |
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