化合物 T16773
| 中文名稱 | 化合物 T16773 |
|---|---|
| 中文同義詞 | 化合物 T16773;2'-(4-氨基苯基)-1H,3'H-[2,5'-聯(lián)苯并[D]咪唑]-5-胺;化合物RO 90-7501;RO 90-7501,AΒ42原纖維形成的抑制劑 |
| 英文名稱 | RO 90-7501 |
| 英文同義詞 | 2'-(4-aMinophenyl)-1H,3'H-2,5'-bibenzo[d]iMidazol-6-aMine;RO90-7501; RO 907501;2'-(4-Aminophenyl)-1H,3'H-[2,5'-bibenzo[d]imidazol]-5-amine;2,5'-Bi-1H-benzimidazol]-5-amine, 2'-(4-aminophenyl)- |
| CAS號(hào) | 293762-45-5 |
| 分子式 | C20H16N6 |
| 分子量 | 340.388 |
| EINECS號(hào) | |
| 相關(guān)類別 | 標(biāo)準(zhǔn)品 |
| Mol文件 | 293762-45-5.mol |
| 結(jié)構(gòu)式 |  |
化合物 T16773 性質(zhì)
| 儲(chǔ)存條件 | Store at +4°C |
|---|---|
| 溶解度 | 二甲基亞砜：20 毫克/毫升 |
| 形態(tài) | 固體 |
| 顏色 | 棕色 |
|
Amyloid β42
|
ATM
|
Protein phosphatase 5
|
Apoptosis
|
Ro 90-7501 significantly enhances radiosensitivity compared with control HeLa and ME-180 cells. Ro 90-7501 significantly increases apoptosis and impaired cell cycle after irradiation. Ro 90-7501 suppresses the phosphorylation of ATM and its downstream proteins, such as H2AX, Chk1, and Chk2, after irradiation.
RO 90-7501, itself affects neither IFN-β nor NFκB promoter activity, but significantly enhances poly I:C-induced IFN-β promoter activation and inhibits the activation of NFκB in a dose-dependent manner. Treatment of cells with RO 90-7501 significantly enhances the antiviral activity of poly I:C.
Ro 90-7501 (5 μg/g; intraperitoneal injection; daily; for 21 days; female BALB/c nude mice) treatment significantly delays tumor growth and significantly decreases tumor volume.
| Animal Model: | Female BALB/c nude mice (8-week-old) with HeLa cells under irradiation |
| Dosage: | 5 μg/g |
| Administration: | Intraperitoneal injection; daily; for 21 days |
| Result: | Tumor growth was significantly delayed in the combination group. Tumor volume was also significantly decreased in the irradiation group. |