TH1020
| 中文名稱 | TH1020 |
|---|---|
| 中文同義詞 | 4-((4-芐基-5-(吡啶-4-基)-4H-1,2,4-三唑-3-基)硫基)吡啶并[3',2':4,5]噻吩并[3,2-D]嘧啶;化合物TH1020;TH 1020,TOLL樣受體(TLR)5 / FLAGELLIN復(fù)合拮抗劑 |
| 英文名稱 | TH1020 |
| 英文同義詞 | TH1020;4-[[4-(Phenylmethyl)-5-(4-pyridinyl)-4H-1,2,4-triazol-3-yl]thio]-pyrido[3',2':4,5]thieno[3,2-d]pyrimidine;4-[[4-(Phenylmethyl)-5-(4-pyridinyl)-4H-1,2,4-triazol-3-yl]thio]-pyrido[3',2';TH1020 >=95% (HPLC);4-((4-Benzyl-5-(pyridin-4-yl)-4H-1,2,4-triazol-3-yl)thio)pyrido[3',2':4,5]thieno[3,2-d]pyrimidine;interaction,inhibit,Bacterial,flagellin,TH-1020,TH1020,Toll-like Receptor (TLR),TLR5,protein-protein,TNF-α,Inhibitor,TH 1020;Pyrido[3',2':4,5]thieno[3,2-d]pyrimidine, 4-[[4-(phenylmethyl)-5-(4-pyridinyl)-4H-1,2,4-triazol-3-yl]thio]-;6-{[4-benzyl-5-(pyridin-4-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}-8-thia-3,5,10-triazatricyclo[7.4.0.02,?]trideca-1(9),2(7),3,5,10,12-hexaene |
| CAS號 | 1841460-82-9 |
| 分子式 | C23H15N7S2 |
| 分子量 | 453.54 |
| EINECS號 | |
| 相關(guān)類別 | |
| Mol文件 | 1841460-82-9.mol |
| 結(jié)構(gòu)式 |  |
TH1020 性質(zhì)
| 沸點(diǎn) | 765.8±70.0 °C(Predicted) |
|---|---|
| 密度 | 1.51±0.1 g/cm3(Predicted) |
| 儲存條件 | 2-8°C |
| 溶解度 | 氯仿：1mg/mL |
| 形態(tài) | 粉末 |
| 酸度系數(shù)(pKa) | 1.92±0.10(Predicted) |
| 顏色 | 白色至米色 |
| InChI | InChI=1S/C23H15N7S2/c1-2-5-15(6-3-1)13-30-20(16-8-11-24-12-9-16)28-29-23(30)32-22-19-18(26-14-27-22)17-7-4-10-25-21(17)31-19/h1-12,14H,13H2 |
| InChIKey | CBBXTGWSGPEJEE-UHFFFAOYSA-N |
| SMILES | C1=NC(SC2N(CC3=CC=CC=C3)C(C3C=CN=CC=3)=NN=2)=C2SC3=NC=CC=C3C2=N1 |
TH1020 是一種有效的選擇性的 Toll 樣受體 5 (TLR5)/鞭毛蛋白復(fù)合拮抗劑，IC50 為 0.85 μM。TH1020 抑制鞭毛蛋白誘導(dǎo)的 TLR5 信號傳導(dǎo)，對 TLR2，TLR3，TLR4，TLR7 和 TLR8 無效。
IC50: 0.85 μM (toll-like receptor 5 (TLR5)/flagellin complex)
TH1020 inhibits the downstream signaling transduction mediated by the formation of the TLR5/Flagellin complex. TH1020 is suggested to compete with flagellin and disrupt its association with TLR5. TH1020 almost completely abolishes the TLR5-mediated TNF-α secretion at 0.37 μM.
The IL-17C secretion is almost completely abolished by TH1020 (0.5 μM) in bacterial strain C83901 infected IPEC-J2 cells.
Blocking TLR5 with TH1020 (0.5 μM) dramatically inhibits porcine beta-defensin (pBD)-2, claudin-1 and -2 mRNA expression in C83091 infected IPEC-J2 cells.
安全信息
| 更新日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價(jià)格 |
|---|---|---|---|---|---|
| 2025/05/22 | HY-116961 | TH1020 | 1841460-82-9 | 1 mg | 363元 |
| 2025/05/22 | HY-116961 | TH1020 TH1020 | 1841460-82-9 | 5mg | 800元 |