Lipoxamycin
中文名稱 | Lipoxamycin |
---|---|
中文同義詞 | 化合物 T26308;脂黃霉素半硫酸鹽 |
英文名稱 | Lipoxamycin |
英文同義詞 | Lipoxamycin;Lipoxamycin hemisulfate;U 26146D;U26146D;U-26146D |
CAS號(hào) | 11075-87-9 |
分子式 | C19H38N2O9S |
分子量 | 470.58 |
EINECS號(hào) | |
相關(guān)類別 | |
Mol文件 | 11075-87-9.mol |
結(jié)構(gòu)式 | ![]() |
Lipoxamycin 性質(zhì)
儲(chǔ)存條件 | Store at -20°C |
---|---|
溶解度 | DMSO:40 mg/mL(94.89 mM;超聲加熱并加熱至 60°C) |
形態(tài) | 固體 |
顏色 | 白色至米白色 |
Serine palmitoyltransferase
Lipoxamycin has antifungal activity against a panel of humanpathogenic fungi with better potency against some of the
Candida
species (MIC values, 0.25-16 μg/mL).
Cryptococcus neoformans
is the most sensitive organism, followed by various species of
Candida
. Other filamentous fungi are sensitive to the Lipoxamycin in disk diffusion assays.
Lipoxamycin has a long alkyl chain and an amino-containing polar head group. Lipoxamycin is on the same order of potency as the sphingofungins and also have potent activity against the mammalianenzyme.
Lipoxamycin is highly toxic in mice when applied subeutaneously or topically. Toxicity may be mechanism based, since studies with a Chinese hamster ovary cell mutant have shown that the serine palmitoyltransferase is an essential enzymein mammalian cells.
安全信息
更新日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
---|---|---|---|---|---|
2025/02/08 | HY-119759A | Lipoxamycin hemisulfate | 11075-87-9 | 1 mg | 1420元 |
2025/02/08 | HY-119759A | Lipoxamycin Lipoxamycin hemisulfate | 11075-87-9 | 10 mM * 1 mLin DMSO | 3264元 |