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139290-65-6

139290-65-6

中文名稱139290-65-6
中文同義詞Volinanserin MDL 100907 (R構(gòu)型);VOLINANSERIN MDL 100907 (R構(gòu)型);氟利色林;諾和靈 M100907;(R)-(2,3-二甲氧基苯基)(1-(4-氟苯乙基)哌啶-4-基)甲醇;氟利色林,10 MM DMSO 溶液
英文名稱(R)-(+)-ALPHA-(2,3-DIMETHOXYPHENYL)-1-[2-(4-FLUORO-PHENYL)ETHYL]-4-PIPERIDINE METHANOL
英文同義詞(+)-a-(2,3-Dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol;(aR)-a-(2,3-Dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol;M 100907;R-MDL 100907;(R)-(+)-(-(2,3-Dimethoxyphenyl)-1-[2-(4-fluoro-phenyl)ethyl]-4-piperidine methanol (R,R)-tartrate;4-Piperidinemethanol, 1-[2-(4-fluorophenyl)ethyl]-(-(2,3-dimethoxyphenyl)-, ((R), (R,R)-tartrate;MDL100907-L-tartrate;(R)-(+)-(-(2,3-Dimethoxyphenyl)-1-[2-(4-fluoro-phenyl)ethyl]-4-piperidine methanol
CAS號(hào)139290-65-6
分子式C22H28FNO3
分子量373.46
EINECS號(hào)
相關(guān)類別Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
Mol文件139290-65-6.mol
結(jié)構(gòu)式139290-65-6 結(jié)構(gòu)式

139290-65-6 性質(zhì)

熔點(diǎn)89-91°C
沸點(diǎn)499.4±45.0 °C(Predicted)
密度1.150±0.06 g/cm3(Predicted)
儲(chǔ)存條件2-8°C
溶解度二甲基亞砜:≥20mg/mL
形態(tài)粉末
酸度系數(shù)(pKa)13.93±0.20(Predicted)
顏色灰白色至淺棕色

139290-65-6 用途與合成方法

Volinanserin (Volinanserin Hydrochloride Salt, MDL100907, M 100907, MDL-100,907)是一種高度選擇性的、有效的 5-HT2 receptor 的拮抗劑,其Ki值為0.36 nM。Volananserin 具有治療精神紊亂的藥物活性。
TargetValue
5-HT2 receptor
(Cell-free assay)
0.36 nM(Ki)

Volinanserin (MDL 100907) is a potent antagonist at the 5-HT 2 receptor, with a K i of 0.36 nM, and shows 300-fold selectivity for 5-HT 2 receptor over 5-HT 1c receptor, alpha-1 and DA D 2 receptors. Volinanserin has antipsychotic activity.

Volinanserin (MDL 100907; 0.008-2.0 mg/kg, i.p.) significantly decreases d-amphetamine-stimulated locomotor activity in mice, with an ED 50 of 0.3 mg/kg, but shows no obvious reduction in the base-line locomotor activity in mice. Volinanserin produces atalepsy with an ED 50 of 10-50 mg/kg in rats. Volinanserin does not reduces apomorphine-induced stereotypies or produces catalepsy in rats. Volinanserin (M100907) combined with MK-801 significantly decreases reinforcers at 1 μg/kg, but dose-dependently (10, 100 μg/kg) antagonizes the disruptive effect of MK-801 in rats via i.p. administration. Volinanserin (6.25 μg/kg) enhances the antidepressant-like action of desipramine in rats performing under a DRL 72-s schedule, and elevates the antidepressant-like effect of tranylcypromine.

安全信息

危險(xiǎn)品標(biāo)志N
危險(xiǎn)類別碼50
安全說明61
危險(xiǎn)品運(yùn)輸編號(hào)UN 3077 9 / PGIII
WGK Germany3

MSDS信息

更新日期產(chǎn)品編號(hào)產(chǎn)品名稱CAS號(hào)包裝價(jià)格
2025/02/08HY-14940139290-65-6
Volinanserin
139290-65-65mg1100元
2025/02/08HY-14940139290-65-6
Volinanserin
139290-65-610mM * 1mLin DMSO1210元

139290-65-6 上下游產(chǎn)品信息

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