- NB-598
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- $72.00 / 1mg
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2025-05-02
- CAS:131060-14-5
- Min. Order:
- Purity: 99.4%
- Supply Ability: 10g
- NB-598
-
- $1.00 / 1g
-
2019-12-24
- CAS:131060-14-5
- Min. Order: 1g
- Purity: 99%
- Supply Ability: 20kg
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| Product Name: | NB-598 | | Synonyms: | Benzenemethanamine, 3-([3,3'-bithiophen]-5-ylmethoxy)-N-[(2E)-6,6-dimethyl-2-hepten-4-yn-1-yl]-N-ethyl-;(E)-N-(3-([3,3'-bithiophen]-5-ylmethoxy)benzyl)-N-ethyl-6,6-dimethylhept-2-en-4-yn-1-amine;NB 598,NB-598,inhibit,NB598,Inhibitor;NB-598, 10 mM in DMSO | | CAS: | 131060-14-5 | | MF: | C27H31NOS2 | | MW: | 449.67 | | EINECS: | | | Product Categories: | | | Mol File: | 131060-14-5.mol |  |
| | NB-598 Chemical Properties |
| Melting point | ~60 °C | | Boiling point | 530.7±50.0 °C(Predicted) | | density | 1.122±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Sealed in dry,Store in freezer, under -20°C | | solubility | DMSO: 14 mg/mL | | pka | 7.04±0.50(Predicted) | | form | solid | | color | white |
| | NB-598 Usage And Synthesis |
| Uses | NB-598 is a potent and competitive inhibitor of squalene epoxidase (SE), and suppresses triglyceride biosynthesis through the farnesol pathway. NB-598 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | | Biological Activity | NB-598 is a potent and specific inhibitor of mammalian squalene epoxidase (SQLE) th at suppresses triglyceride biosynthesis through the farnesol pathway. It decreases cholesterol levels in cells. NB-598 exhibit potent cytotoxic effects in subset of f neuroendocrine tumors, such as small cell lung cancers through accumulation of toxic squalene with in sensitive cancer cells. | | References | [1] Xia F, et al. Inhibition of cholesterol biosynthesis impairs insulin secretion and voltage-gated calcium channel function in pancreatic beta-cells. Endocrinology. 2008 Oct;149(10):5136-45. DOI:10.1210/en.2008-0161
[2] Horie M, et al. Effects of NB-598, a potent squalene epoxidase inhibitor, on the apical membrane uptake of cholesterol and basolateral membrane secretion of lipids in Caco-2 cells. Biochem Pharmacol. 1993 Jul 20;46(2):297-305. DOI:10.1016/0006-2952(93)90418-v
[3] Horie M, et al. An inhibitor of squalene epoxidase, NB-598, suppresses the secretion of cholesterol and triacylglycerol and simultaneously reduces apolipoprotein B in HepG2 cells. Biochim Biophys Acta. 1993 May 20;1168(1):45-51. PMID:8504141 |
| | NB-598 Preparation Products And Raw materials |
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