- MA-0204
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- $88.00 / 1mg
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2024-11-19
- CAS:2095128-17-7
- Min. Order:
- Purity: 97.80%
- Supply Ability: 10g
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| | MA-0204 Basic information |
| Product Name: | MA-0204 | | Synonyms: | MA-0204;CS-2841;Hexanoic acid, 3-methyl-6-[2-[[5-methyl-2-[4-(trifluoromethoxy)phenyl]-1H-imidazol-1-yl]methyl]phenoxy]-, (3R)-;MA0204,inhibit,MA 0204,Peroxisome proliferator-activated receptors,MA-0204,PPAR,Inhibitor;(R)-3-methyl-6-(2-((5-methyl-2-(4-(trifluoromethoxy)phenyl)-1H-imidazol-1-yl)methyl)phenoxy)hexanoic acid;(3R)-3-methyl-6-[2-({5-methyl-2-[4-(trifluoromethoxy)phenyl]-1H-imidazol-1-yl}methyl)phenoxy]hexanoic acid;MA-0204, 10 mM in DMSO | | CAS: | 2095128-17-7 | | MF: | C25H27F3N2O4 | | MW: | 476.49 | | EINECS: | | | Product Categories: | | | Mol File: | 2095128-17-7.mol |  |
| | MA-0204 Chemical Properties |
| Boiling point | 611.9±65.0 °C(Predicted) | | density | 1.23±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | form | Solid | | pka | 4.76±0.10(Predicted) | | color | White to off-white |
| | MA-0204 Usage And Synthesis |
| Uses | MA-0204 is a potent, highly selective and orally available peroxisome proliferator activated receptor δ (PPARδ) modulator with EC50s of 0.4 nM, 7.9 nM and 10 nM for human, mouse and rat PPARδ, respectively. Potential treatment for Duchene Muscular Dystrophy (DMD)[1]. | | in vivo | PPARδ (30, 100 mg/kg) increases target gene transcription in the muscle[1]. | | IC 50 | PPARδ: 0.4 nM (EC50, in human); PPARδ: 7.9 nM (EC50, in mouse); PPARδ: 10 nM (EC50, in rat) | | References | [1] Lagu B, et al. Selective PPARδ Modulators Improve Mitochondrial Function: Potential Treatment for Duchenne Muscular Dystrophy (DMD). ACS Med Chem Lett. 2018 Jul 31;9(9):935-940. DOI:10.1021/acsmedchemlett.8b00287 |
| | MA-0204 Preparation Products And Raw materials |
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