PIM1/2 KINASE INHIBITOR VI
中文名稱 | PIM1/2 KINASE INHIBITOR VI |
---|---|
中文同義詞 | 化合物SMI-16A;5-(4-丙氧基亞芐基)噻唑烷-2,4-二酮;化合物SMI-16A,10 MM DMSO 溶液;PIM激酶抑制劑(SMI-16A);抑制劑SMI-16a |
英文名稱 | SMI-16a |
英文同義詞 | SMI-16a;PIM1/2 Kinase Inhibitor VI;SMI-16a(PIM1/2 Kinase Inhibitor VI);SMI-16A;SMI 16A;SMI16A;2,4-Thiazolidinedione, 5-[(4-propoxyphenyl)methylene]-;SMI-16a,SMI 16a,inhibit,SMI16a,Pim,Inhibitor,Pim kinases;5-(4-propoxybenzylidene)thiazolidine-2,4-dione;SMI-16a, 10 mM in DMSO |
CAS號 | 587852-28-6 |
分子式 | C13H13NO3S |
分子量 | 263.31 |
EINECS號 | |
相關類別 | 細胞生物學試劑 |
Mol文件 | 587852-28-6.mol |
結構式 | ![]() |
PIM1/2 KINASE INHIBITOR VI 性質
熔點 | 186.3-188.4 °C |
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密度 | 1.303±0.06 g/cm3(Predicted) |
儲存條件 | 2-8°C(protect from light) |
溶解度 | 乙醇:3.0(最大濃度 mg/mL);11.39(最大濃度 mM) |
形態(tài) | 固體 |
酸度系數(pKa) | 7.27±0.20(Predicted) |
顏色 | 淺黃至黃色 |
Target | Value |
Pim2
() | 20 nM |
Pim1
() | 150 nM |
SMI-16a has excellent potency for inhibition of both Pim-1 and Pim-2. Treatment with Pim-2 short-interference RNA as well as the Pim inhibitor SMI-16a successfully restores osteoblastogenesis suppressed by all the above inhibitory factors and MM cells. The SMI-16a treatment potentiates BMP-2-mediated anabolic signaling while suppressing TGF-β signaling.
Mice tolerate intraperitoneal dose of SMI-16a is 50 mg/kg daily for 5 days, while 100 mg/kg is overtly toxic. Treatment of the animals with SMI-16a for 5 days per week reduces the growth of tumors by approximately 50% and does not cause a loss of body weight. Subchronic dosing with SMI-16a does not affect the levels of red, white blood cells, including lymphocytes, monocytes, and granulocytes, indicating that the compound does not have myelosuppressive effects. SMI-16a does not have toxicity toward the liver as the albumin, alkaline phosphatase, and alanine aminotransferase levels are unchanged . SMI-16a effectively prevents bone destruction while suppressing MM tumor growth in MM animal models.
安全信息
更新日期 | 產品編號 | 產品名稱 | CAS號 | 包裝 | 價格 |
---|---|---|---|---|---|
2025/05/22 | HY-101947 | SMI-16a | 587852-28-6 | 1 mg | 304元 |
2025/05/22 | HY-101947 | PIM1/2 KINASE INHIBITOR VI SMI-16a | 587852-28-6 | 5mg | 790元 |