4-Cyclopropyl-9-(4-quinolin-7-yl-benzenesulfonyl)-1-oxa-4,9-diaza-spiro[5.5]undecan-3-one manufacturers
- FASN-IN-4
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- $1850.00 / 100mg
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2024-10-28
- CAS:1375105-96-6
- Min. Order:
- Purity:
- Supply Ability: 10g
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| | 4-Cyclopropyl-9-(4-quinolin-7-yl-benzenesulfonyl)-1-oxa-4,9-diaza-spiro[5.5]undecan-3-one Basic information |
| | 4-Cyclopropyl-9-(4-quinolin-7-yl-benzenesulfonyl)-1-oxa-4,9-diaza-spiro[5.5]undecan-3-one Chemical Properties |
| Boiling point | 712.9±70.0 °C(Predicted) | | density | 1.42±0.1 g/cm3(Predicted) | | pka | 3.98±0.14(Predicted) | | form | Solid | | color | White to off-white |
| | 4-Cyclopropyl-9-(4-quinolin-7-yl-benzenesulfonyl)-1-oxa-4,9-diaza-spiro[5.5]undecan-3-one Usage And Synthesis |
| Uses | FASN-IN-4 is a potent inhibitor of fatty acid synthase (FASN) with an IC50 of 10 nM (WO2012064642A1, compound 29)[1]. FASN-IN-4 also inhibits SARS-CoV-2 with an EC50 of 18.6?nM[2]. | | References | [1] Nicholas D. Adams, et al. Fatty acid synthase inhibitors. WO2012064642A1.
[2] Junjun Chu, et al. Pharmacological inhibition of fatty acid synthesis blocks SARS-CoV-2 replication. Nat Metab. 2021 Nov;3(11):1466-1475. DOI:10.1038/s42255-021-00479-4 |
| | 4-Cyclopropyl-9-(4-quinolin-7-yl-benzenesulfonyl)-1-oxa-4,9-diaza-spiro[5.5]undecan-3-one Preparation Products And Raw materials |
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