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FG 2216

FG 2216 Suppliers list
Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: +undefined-21-51877795
Email: ivan@atkchemical.com
Products Intro: Product Name:FG-2216
CAS:223387-75-5
Purity:98% Package:10MG;50MG;100MG,1G,5G,10G.100G
Company Name: career henan chemical co
Tel: +86-0371-86658258 +8613203830695
Email: factory@coreychem.com
Products Intro: Product Name:FG 2216
CAS:223387-75-5
Purity:99% Package:1g;1USD
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Products Intro: Product Name:FG-2216
CAS:223387-75-5
Purity:99% Package:5mg;29USD|10mg;53USD|25mg;107USD Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: InvivoChem
Tel: +1-708-310-1919 +1-13798911105
Email: sales@invivochem.cn
Products Intro: Product Name:FG-2216
CAS:223387-75-5
Purity:98% Package:5mg Remarks:V0298
Company Name: ShenZhen Trendseen Biological Technology Co.,Ltd.
Tel: 13417589054
Email: trendseenbio@gmail.com
Products Intro: Product Name:FG2216
CAS:223387-75-5
Purity:99% Package:1kg；25kg

FG 2216 manufacturers

  • FG-2216
  • FG-2216 pictures
  • $33.00 / 2mg
  • 2024-11-19
  • CAS:223387-75-5
  • Min. Order:
  • Purity: 99%
  • Supply Ability: 10g
  • FG 2216
  • FG 2216 pictures
  • $1.00 / 1g
  • 2019-12-24
  • CAS:223387-75-5
  • Min. Order: 1g
  • Purity: 99%
  • Supply Ability: 20kg
FG 2216 Basic information
Product Name:FG 2216
Synonyms:FG 2216;FG2216;FG-2216;[[(1-Chloro-4-hydroxyisoquinolin-3-yl)carbonyl]amino]acetic acid;FG 2216 (erythropoietic agent);YM 311;(Z)-2-(((1-CHLORO-4-HYDROXYISOQUINOLIN-3-YL)(HYDROXY)METHYLENE)AMINO)ACETIC ACID;N-[(1-Chloro-4-hydroxy-3-isoquinolinyl)carbonyl]glycine
CAS:223387-75-5
MF:C12H9ClN2O4
MW:280.66
EINECS:
Product Categories:Inhibitors
Mol File:223387-75-5.mol
FG 2216 Structure
FG 2216 Chemical Properties
Boiling point 670.6±55.0 °C(Predicted)
density 1.571±0.06 g/cm3(Predicted)
storage temp. -20°C
solubility insoluble in H2O; ≥14.05 mg/mL in DMSO; ≥5.12 mg/mL in EtOH with ultrasonic
form powder
pka3.20±0.10(Predicted)
color white to beige
Safety Information
MSDS Information
FG 2216 Usage And Synthesis
DescriptionFG-2216 is an inhibitor of hypoxia-inducible factor prolyl hydroxylase 2 (HIF-PH2; IC50 = 3.9 micromolar). It has been shown to reversibly stimulate erythropoietin secretion at 100 μM in vitro and to increase hematocrit, red blood cell count, and hemoglobin levels at 50 mg/kg in mice.
UsesFG 2216 is an erythropoietic agent which is orally active prolyl-hydroxylase inhibitor which increases erythropoietin production in end-stage kidney disease.
Biochem/physiol ActionsBIQ (FG-2216) is an orally available and potent inhibitor of prolyl-hydroxylase (PHD). BIQ induces significant and reversible plasma erythropoietin (EPO) levels in vitro and in hemodialysis patients.
references1. hsieh mm, linde ns, wynter a et al. hif prolyl hydroxylase inhibitionresults in endogenous erythropoietin induction, erythrocytosis, and modest fetal hemoglobin expression in rhesus macaques. blood. 2007 sep 15;110(6):2140-7.
FG 2216 Preparation Products And Raw materials
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