207987-59-5
| 中文名稱 | 207987-59-5 |
|---|---|
| 中文同義詞 | 化合物 T12771;化合物 RS-601 |
| 英文名稱 | RS-601 |
| 英文同義詞 | RS-601;Benzenebutanoic acid, 4-[5,5,6,6,6-pentafluoro-1-[[(4-fluorophenyl)sulfonyl]amino]hexyl]-;RS 601,RS601 |
| CAS號(hào) | 207987-59-5 |
| 分子式 | C22H23F6NO4S |
| 分子量 | 511.48 |
| EINECS號(hào) | |
| 相關(guān)類別 | |
| Mol文件 | 207987-59-5.mol |
| 結(jié)構(gòu)式 |  |
207987-59-5 性質(zhì)
| 沸點(diǎn) | 563.3±60.0 °C(Predicted) |
|---|---|
| 密度 | 1.360±0.06 g/cm3(Predicted) |
| 儲(chǔ)存條件 | Store at -20°C |
| 溶解度 | 溶于二甲基亞砜 |
| 酸度系數(shù)(pKa) | 4.75±0.10(Predicted) |
RS-601 是有效的 leukotriene D4/thromboxane A2 雙重抑制劑，具有平喘作用。
|
LTD 4
|
TXA 2 Receptor
|
RS-601 (1-10 mg/kg) clearly inhibits the bronchoconstriction induced by intravenous administration of U-46619 and LTD4 in a dose-dependent fashion in guinea pigs. RS-1452 (10 mg/kg) significantly inhibits U-46619-induced bronchoconstriction, respectively. RS-601 significantly inhibits the late-phase response and LPS-induced AHR at a dose of 10 mg/kg, but does not affect biphasic bronchial responses. RS-601 (3 and 10 mg/kg) also clearly inhibits the AHR.