1913269-12-1
| 中文名稱(chēng) | 1913269-12-1 |
|---|---|
| 中文同義詞 | 化合物KN-93 PHOSPHATE,10 MM DMSO 溶液 |
| 英文名稱(chēng) | KN-93 (phosphate) |
| 英文同義詞 | KN93 Phosphate,KN 93 Phosphate;KN-93 Phosphate, 10 mM in DMSO |
| CAS號(hào) | 1913269-12-1 |
| 分子式 | C26H32ClN2O8PS |
| 分子量 | 599.03 |
| EINECS號(hào) | |
| 相關(guān)類(lèi)別 | |
| Mol文件 | 1913269-12-1.mol |
| 結(jié)構(gòu)式 |  |
1913269-12-1 性質(zhì)
| 形態(tài) | 固體 |
|---|---|
| 顏色 | 白色至米白色 |
Ki: 370 nM (CaMK-II)
After 2 days of KN-93 treatment, 95% of cells are arrested in G1. G1 arrest is reversible; 1 day after KN-93 release, a peak of cells had progressed into S and G2-M. KN-93 also blocks cell growth stimulated by basic fibroblast growth factor, platelet-derived growth factor-BB, and epidermal growth factor in NIH 3T3 fibroblasts. KN-93 inhibits the H + , K + -ATPase activity but strongly dissipates the proton gradient formed in the gastric membrane vesicles and reduces the volume of luminal space. KN-93 (0.5 μM) prevents increased LV developed pressure during action potential prolongation and early afterdepolarizations. Ca 2+ -independent CaM kinase activity is increased during early afterdepolarizations and this increase is prevented by KN-93.