- CARM1-IN-1
-
- $31.00 / 1mg
-
2025-05-27
- CAS:1020399-49-8
- Min. Order:
- Purity: 97.35%
- Supply Ability: 10g
- CARM1-IN-1
-
- $31.00 / 1mg
-
2025-05-27
- CAS:1020399-49-8
- Min. Order:
- Purity: 97.35%
- Supply Ability: 10g
|
| | CARM1-IN-1 Basic information |
| Product Name: | CARM1-IN-1 | | Synonyms: | CARM1-IN-1;PRMT4/CARM1 Inhibitor;CARM1 inhibitor 1;CARM1-IN-7g;4-Piperidinone, 3,5-bis[(3-bromo-4-hydroxyphenyl)methylene]-1-(phenylmethyl)-;CARM1-IN-1, 10 mM in DMSO | | CAS: | 1020399-49-8 | | MF: | C26H21Br2NO3 | | MW: | 555.26 | | EINECS: | | | Product Categories: | | | Mol File: | 1020399-49-8.mol |  |
| | CARM1-IN-1 Chemical Properties |
| Boiling point | 659.8±55.0 °C(Predicted) | | density | 1.647±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS(pH 7.2) (1:4): 0.2 mg/mL; Ethanol: 0.25 mg/mL | | form | A crystalline solid | | pka | 7.77±0.35(Predicted) | | color | Yellow to orange |
| | CARM1-IN-1 Usage And Synthesis |
| Uses | CARM1-IN-1 (compound 7g) is a highly potent and selective inhibitor of CARM1 (IC50=8.6 μM, CARM1/PABP1), with low inhibitory activity against PRMT1 and SET7 (IC50 >667 μM). CARM1-IN-1 inhibits the methylation activity of CARM1 and the methylation levels of different substrates, such as PABP1, CA150, SmB, and H3. CARM1-IN-1 also inhibits the promoter activity of prostate-specific antigen (PSA) without significant cytotoxicity[1]. | | Biological Activity | Cell permeable: yes', 'Primary Target
PRMT4', 'Reversible: yes', 'Secondary Target
SET7', 'Target IC50: CARM1-mediated methylation over PRMT1 and SET7 (IC60 = 7.1, 63 and 943 μM, | | IC 50 | PRMT4 | | References | [1] Cheng D, et al. Novel 3,5-bis(bromohydroxybenzylidene)piperidin-4-ones as coactivator-associated arginine methyltransferase 1 inhibitors: enzyme selectivity and cellular activity. J Med Chem. 2011 Jul 14;54(13):4928-32. DOI:10.1021/jm200453n |
| | CARM1-IN-1 Preparation Products And Raw materials |
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