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MipoMersen sodiuM

MipoMersen sodiuM Suppliers list
Company Name: Innovassynth Technologies (I) Ltd.  
Tel: +91-2192260100 +91-7208872197
Email: marketing@innovassynth.com
Products Intro: Product Name:Mipomersen sodium
Purity:98% Package:1 kg,5 kg, 10 kg,25kg and 1 MT
Company Name: S.Z. PhyStandard Bio-Tech. Co., Ltd.  
Tel: 0755-83725681-603
Email:
Products Intro: Product Name:mipomersen sodium
Purity:HPLC>=98% Package:10-100mg
Company Name: EnliPharma Technology Co., Ltd  
Tel: 0551-66399836 18955197623
Email: sales@enlipharma.com
Products Intro: Product Name:MipoMersen sodiuM
CAS:629167-92-6
Purity:>97% Package:1g,5g,100g,500g,1Kg,10kg
Company Name: Nugene Biopharm Science (Hangzhou) Co., Ltd.  
Tel: 13326014885
Email: service@nugene.com.cn
Products Intro: Product Name:Mipomersen sodium
Purity:95% Package:1gram;5gram;10gram
Company Name: CLEARSYNTH LABS LTD.  
Tel: +91-22-45045900
Email: sales@clearsynth.com
Products Intro: Product Name:Mipomersen Sodium
CAS:629167-92-6
MipoMersen sodiuM Basic information
Product Name:MipoMersen sodiuM
Synonyms:MipoMersen sodiuM
CAS:629167-92-6
MF:C230H305N67Na19O122P19S19
MW:7594.800489
EINECS:
Product Categories:APIs
Mol File:629167-92-6.mol
MipoMersen sodiuM Structure
MipoMersen sodiuM Chemical Properties
storage temp. Store at -20°C
form Solid
color White to off-white
Safety Information
MSDS Information
MipoMersen sodiuM Usage And Synthesis
DescriptionMipomersen is a 20-mer phosphorothioate oligonuleotide with underlined residues containing 2'-O-(2-methoxyethyl) nucleosides; all other residues are 2'-deoxynucleosides. Substitution at the 5-position of cytosine (C) and uracil (U) bases with a methyl group is indicated by MeC or MeU. Mipomersen (also known as ISIS 301012) was approved with orphan drug status by the US FDA in January 2013 as an adjunct to lipid-lowering medications and diet to reduce low density lipoprotein-cholesterol (LDLC), apolipoprotein B (Apo B), total cholesterol (TC), and non-high density lipoprotein-cholesterol (non-HDL-C) in patients with homozygous familial hypercholesterolemia (HoFH). Mipomersen is an anti-sense oligonucleotide (ASO) designed to inhibit Apo B100 transcription by Watson Crick pairing to the mRNA sequence to target the complex for silencing and elimination, often via RNase H1 degradation.Mipomersen is synthesized via solid-phase nucleotide synthesis involving sequential addition of nucleotide phosphoramidates, with subsequent phosphorothiolation via phenylacetyldisulfide.
OriginatorISIS Pharmaceuticals (United States)
Brand nameKynamro
MipoMersen sodiuM Preparation Products And Raw materials
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