- Penitrem A
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- $695.00 / 10mg
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2025-04-28
- CAS:12627-35-9
- Min. Order:
- Purity:
- Supply Ability: 10g
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| | PENITREM A Basic information |
| Product Name: | PENITREM A | | Synonyms: | TREMORTIN A;Penitrem A from Penicillium paxilli;PENITREM A;PENITREM A, PENICILLIUM PAXILLI;penitrem A from penicillium palitans;Penitrem A Nsc354845;JDUWHZOLEDOQSR-JKPSMKLGSA-N;2R,3S,3aR,4aS,4bS,6aR,7S,7dR,8R,9aR,14bS,14cR,16aS)-12-chloro-3,3a,6a,8,9,9a,10,11,14,14b,14c,15,16,16a-tetradecahydro-14b,14c,17,17-tetramethyl-10-methylene-2-(1-methylethenyl)-7,8-(epoxymethano)-2H,6H-cyclobuta[5,6]benz[1,2-e]oxireno[4',4'a]-1-benzopyrano[5',6':6,7]indeno[1,2-b]indole-3,4b,7d(5H,7H)-triol | | CAS: | 12627-35-9 | | MF: | C37H44ClNO6 | | MW: | 634.2 | | EINECS: | 634-132-0 | | Product Categories: | antibiotic | | Mol File: | 12627-35-9.mol |  |
| | PENITREM A Chemical Properties |
| Melting point | 238°C | | density | 1.0241 (rough estimate) | | refractive index | 1.6000 (estimate) | | storage temp. | 2-8°C | | solubility | Soluble in DMSO (up to 6 mg/ml) | | form | White solid. | | pka | 13.22±0.70(Predicted) | | color | Amorphous solid | | Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
| Hazard Codes | T+,T | | Risk Statements | 26/27/28 | | Safety Statements | 36/37/39-45 | | RIDADR | UN 2811 6.1/PG 2 | | WGK Germany | 3 | | RTECS | RY7535000 | | HazardClass | 6.1(a) | | PackingGroup | II | | HS Code | 29349990 | | Toxicity | LD50 orl-mus: 10 mg/kg 41KEAL -,108,78 |
| | PENITREM A Usage And Synthesis |
| Description | Penitrem A (12627-35-9) is a fungal mycotoxin that acts as a selective, irreversible blocker of the smooth muscle high conductance Ca2+-activated K+?(BK, KCa1.1) channel (100% block at 10 nM).1?Displays brain neurotoxicity in rats along with dose-dependent convulsions and death.2?An important tool for studying the role of BK channels in vascular function which is effective in cellular, tissue and?in vivo?experiments.3?Inhibits BK channels in inside-out and cell-attached patches, whereas iberiotoxin (considered the gold standard BK channel blocker) does not.3?May be used to partially ablate Purkinje cells in immature rat cerebellum providing a model for neural stem cell transplantation studies.4 | | Chemical Properties | Solid | | Occurrence | A series of closely related metabolites of Penicillium crustosum has recently been isolated and the components separated chromatographically. Penitrem A forms colourless crystals from EtOH. | | Uses | Penitrem A has been used as Ca2+-Activated K+ (BK) channel blocker to study its effect on BK current in bag cell neurons. | | Uses | Penitrem A is a tremorgenic mycotoxin isolated from Penicillium species. Penitrem A is a selective blocker of high-conductance Ca2+-activated potassium channels. | | Definition | ChEBI: Penitrem A is an organooxygen compound and an organic heterotricyclic compound. | | Biochem/physiol Actions | Penitrem A intoxication causes ataxia, polypnea, and sustained tremors and may lead to seizures and death. Penitrem A affects the central and peripheral nervous system. It impairs the GABAergic neurotransmission in the cerebellum. | | Safety Profile | Poison by ingestion and intraperitoneal routes. An experimental teratogen. When heated to decomposition it emits very toxic fumes of Clí and NOx. | | storage | -20°C | | References | References/Citations:
(1) Knaus et al. (1994), Tremorgenic Indole Alkaloids Potently Inhibit Smooth Muscle High-Conductance Calcium-Activated Potassium Channels; Biochemistry, 33 5819
(2) Breton et al. (1998), Brain neurotoxicity of Penitrem A: electrophysiological, behavioral and histopathological study; Toxicon., 36 645
(3) Asano et al. (2012), Penitrem A as a tool for understanding the role of large conductance Ca(2+)/voltage-sensitive K(+) channels in vascular function; J. Pharmacol. Exp.Ther., 342 453
(4) Lu et al. (2008), Toxin-produced Purkinje cell death: a model for neural stem cell transplantation studies; Brain Res. 1207 207
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| | PENITREM A Preparation Products And Raw materials |
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