BAY-293 manufacturers
- BAY-293
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- $48.00 / 1mg
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2024-11-19
- CAS:2244904-70-7
- Min. Order:
- Purity: 96.8%
- Supply Ability: 10g
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| | BAY-293 Basic information |
| Product Name: | BAY-293 | | Synonyms: | BAY-293;(R)-(6,7-Dimethoxy-2-methyl-quinazolin-4-yl)-[1-[4-(2-methylaminomethyl-phenyl)-thiophen-2-yl]-ethyl]-amine;BAY-293;BAY 293;BAY293;(R)-6,7-dimethoxy-2-methyl-N-(1-(4-(2-((methylamino)methyl)phenyl)thiophen-2-yl)ethyl)quinazolin-4-amine;4-Quinazolinamine, 6,7-dimethoxy-2-methyl-N-[(1R)-1-[4-[2-[(methylamino)methyl]phenyl]-2-thienyl]ethyl]-;6,7-dimethoxy-2-methyl-N-[(1R)-1-[4-[2-(methylaminomethyl)phenyl]-2-thienyl]ethyl]quinazolin-4-amine;Inhibitor,BAY-293,BAY293,inhibit,BAY 293,Ras;BAY-293, 10 mM in DMSO | | CAS: | 2244904-70-7 | | MF: | C25H28N4O2S | | MW: | 448.58 | | EINECS: | | | Product Categories: | | | Mol File: | 2244904-70-7.mol |  |
| | BAY-293 Chemical Properties |
| Boiling point | 553.4±50.0 °C(Predicted) | | density | 1.218±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C(protect from light) | | solubility | DMSO: soluble | | form | A solid | | pka | 9.61±0.10(Predicted) | | color | White to light yellow | | optical activity | [α]/D -85.0 to -103.0°, c =1.0 in DMSO |
| | BAY-293 Usage And Synthesis |
| Uses | 6,7-Dimethoxy-2-methyl-N-[(1R)-1-[4-[2-[(methylamino)methyl]phenyl]-2-thienyl]ethyl]-4-quinazolinamine is an effective and selective inhibitor of SOS1, blocking RAS activation via disruption of the KRAS-SOS1 interaction without significantly targeting the EGFR receptor. Thus, it has potential use in treatment of hyperproliferative disorders. | | Biological Activity | BAY-293 selectively inhibits SOS1-mediated KRAS activation (IC50 = 52 nM; 50 nM wt or G12C hKRAS & 10 nM SOS1cat) via direct SOS1 binding, blocking SOS1-KRAS interaction (IC50 = 21 nM; 10 nM hSOS1c at & 5 nM hKRAS G12C) without affecting (IC50 >20 μM) CRAF RBD-KRAS interaction, KRAS G12C activation by SOS2, Cdc42 activation by DBS, or EGFR kinase activity. BAY-293 downregulates cellular active RAS (IC50 = 200 nM/Calu-1, 410 nM/HeLa) and downstream ERK phosphorylation (K-562, 150 nM/Calu-1) with good target selectivity as assessed over 358 kinases (<37% inhibition at 1 μM) and a panel of 77 GPCRs, transporters, nuclear receptors and enzymes. | | IC 50 | KRAS-SOS1: 21 nM (IC50) | | storage | Store at -20°C |
| | BAY-293 Preparation Products And Raw materials |
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