3,4,5,4'-四甲氧基二苯乙烯
| 中文名稱 | 3,4,5,4'-四甲氧基二苯乙烯 |
|---|---|
| 中文同義詞 | 3,4,5,4'-四甲氧基二苯乙烯;化合物DMU-212;(E)-3,4,5,4'-四甲氧基苯乙烯;(E)-3,4,5,4'-四甲氧基二苯乙烯;3,4,5,4'-四甲氧基二苯乙烯;(E)-3,4,5,4'-四甲氧基苯乙烯 |
| 英文名稱 | 3,4,5,4'-TETRAMETHOXYSTILBENE |
| 英文同義詞 | 3,4,5,4'-TETRAMETHOXYSTILBENE;(E)-1,2,3-Trimethoxy-5-[2-(4-methoxyphenyl)ethenyl]benzene;DMU 212;(E)-3,4,5,4′-Tetramethoxystilbene;1,2,3-Trimethoxy-5-[(1E)-2-(4-methoxyphenyl)ethenyl]-benzene;DMU-212;DMU 212;DMU212;Benzene, 1,2,3-trimethoxy-5-[(1E)-2-(4-methoxyphenyl)ethenyl]-;(E)-3,4,5,4'-Tetramethoxystilbene >=98% (HPLC) |
| CAS號(hào) | 134029-62-2 |
| 分子式 | C18H20O4 |
| 分子量 | 300.349 |
| EINECS號(hào) | 1312995-182-4 |
| 相關(guān)類別 | |
| Mol文件 | 134029-62-2.mol |
| 結(jié)構(gòu)式 |  |
3,4,5,4'-四甲氧基二苯乙烯 性質(zhì)
| 熔點(diǎn) | 157-159℃ |
|---|---|
| 沸點(diǎn) | 444.0±40.0 °C(Predicted) |
| 密度 | 1.117 |
| 儲(chǔ)存條件 | 2-8°C |
| 溶解度 | DMSO：可溶5mg/mL，澄清（加熱） |
| 形態(tài) | 粉末 |
| 顏色 | 白色至米色 |
DMU-212 是一種白藜蘆醇 (HY-16561) 甲基化衍生物，具有抗分裂、抗增殖、抗氧化和促進(jìn)細(xì)胞凋亡的活性。DMU-212 通過誘導(dǎo)凋亡 (apoptosis) 和激活 ERK1/2 蛋白導(dǎo)致有絲分裂停止。DMU-212 具有口服活性。
DMU-212 (0.3125-40 μM) inhibits growth of A375, MeWo, Bro and M5 cells human melanoma cells.
DMU-212 (30-50 μM; 24 hours) induces upregulation of cell cycle inhibitors, apoptosis and ERK activation in A375 cells.
DMU-212 induces upregulation of cell cycle inhibitors, apoptosis and ERK activation in A375 cells.
DMU-212 induces G2/M arrest and apoptosis in cancer cells.
DMU-212 induces mitotic arrest, apoptosis and activation of ERK1/2 protein.
Cell Proliferation Assay
| Cell Line: | A375 cells, MeWo cells, M5 cells, Bro cells |
| Concentration: | 0.3125 μM, 0,625 μM, 1.25 μM, 2.5 μM, 5 μM, 10 μM, 20 μM, 40 μM |
| Incubation Time: | 96 hours |
| Result: | Inhibited the cellular proliferation of human melanoma cells at submicromolar or micromolar concentrations (IC 50 =0.5 μM for A375 and Bro and IC 50 = 1.25 μM for MeWo and M5 cells). |
Cell Cycle Analysis
| Cell Line: | A375 cells |
| Concentration: | 20 μM, 30 μM, 50 μM |
| Incubation Time: | 24 hours |
| Result: | Caused a marked increase in the levels of p21, p53 and cyclin B1 proteins with a concomitant decrease in the levels of cyclin A2. |
Western Blot Analysis
| Cell Line: | A375 cells |
| Concentration: | 20 μM, 30 μM, 50 μM |
| Incubation Time: | 24 hours |
| Result: | Significant upregulation of Bax, caspase 3 and caspase 9 protein levels, while the levels of the anti-apoptotic protein Bcl-2 were decreased. |
DMU-212 (50 mg/kg; i.g.; three times a week; for 14 days) inhibits tumor growth in xenograft model of human ovarian cancer.
| Animal Model: | 6-weeks-old SCID female mice (20-24 g), with ovarian cancer xenografts |
| Dosage: | 50 mg/kg |
| Administration: | Oral gavage, three times a week, for 14 days |
| Result: | Lower tumor burden. |
安全信息
| WGK Germany | 3 |
|---|
| 更新日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
|---|---|---|---|---|---|
| 2024/11/08 | HY-137977 | DMU-212 | 1 mg | 248元 | |
| 2024/11/08 | HY-137977 | 3,4,5,4'-四甲氧基二苯乙烯 DMU-212 | 134029-62-2 | 10mM * 1mLin DMSO | 550元 |