| Company Name: |
R&D Systems, Inc
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| Tel: |
18003437475 18003437475 |
| Email: |
rdname@qq.com |
| Products Intro: |
Product Name:Miro1 Reducer
CAS:2624336-91-8
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| | Urea, N-(3-fluorophenyl)-N'-[4-[[6-(1H-imidazol-1-yl)-4-pyrimidinyl]amino]phenyl]-, hydrochloride (1:1) Basic information |
| | Urea, N-(3-fluorophenyl)-N'-[4-[[6-(1H-imidazol-1-yl)-4-pyrimidinyl]amino]phenyl]-, hydrochloride (1:1) Chemical Properties |
| solubility | Soluble to 100 mM in DMSO | | form | Solid | | color | Light yellow to yellow |
| | Urea, N-(3-fluorophenyl)-N'-[4-[[6-(1H-imidazol-1-yl)-4-pyrimidinyl]amino]phenyl]-, hydrochloride (1:1) Usage And Synthesis |
| Uses | Miro1 Reducer is a small molecule that can repair this defect of Miro1 in Parkinson's disease (PD) fibroblasts. Miro1 Reducer reduces the delayed mitophagy phenotype in PD fibroblasts. Miro1 Reducer reduces Miro1 protein levels in dose-dependent manner (IC50 = 7.8 mM)[1]. | | Biological Activity | Miro1 Reducer is a promotes proteasomal degradation of Miro1 (mitochondrial Rho GTPase 1). Reduces Miro1 levels in fibroblasts from Parkinson's disease (PD) patients (IC50 = 7.8 μM). Exhibits no significant effect on related outer mitochondrial membrane protein Mitofusin. Reduces stress-induced degeneration of dopaminergic neurons derived from PD patient iPSCs. Rescues age-dependent neuronal loss and prolongs lifespan in fly PD models. | | storage | Store at -20°C | | References | [1] Hsieh CH, et al. Miro1 Marks Parkinson's Disease Subset and Miro1 Reducer Rescues Neuron Loss in Parkinson's Models. Cell Metab. 2019 Dec 3;30(6):1131-1140.e7. DOI:10.1016/j.cmet.2019.08.023 |
| | Urea, N-(3-fluorophenyl)-N'-[4-[[6-(1H-imidazol-1-yl)-4-pyrimidinyl]amino]phenyl]-, hydrochloride (1:1) Preparation Products And Raw materials |
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