Company Name: |
TargetMol Chemicals Inc.
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15002134094 |
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marketing@targetmol.cn |
Products Intro: |
Product Name:GSK2850163 hydrochloride CAS:2319838-09-8 Package:25mg/RMB 10600;100mg/RMB 17500;50mg/RMB 13800
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2,7-Diazaspiro[4.5]decane-7-carboxamide, 2-[(3,4-dichlorophenyl)methyl]-N-[(4-methylphenyl)methyl]-, hydrochloride (1:1), (5R)- manufacturers
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| 2,7-Diazaspiro[4.5]decane-7-carboxamide, 2-[(3,4-dichlorophenyl)methyl]-N-[(4-methylphenyl)methyl]-, hydrochloride (1:1), (5R)- Basic information |
Product Name: | 2,7-Diazaspiro[4.5]decane-7-carboxamide, 2-[(3,4-dichlorophenyl)methyl]-N-[(4-methylphenyl)methyl]-, hydrochloride (1:1), (5R)- | Synonyms: | 2,7-Diazaspiro[4.5]decane-7-carboxamide, 2-[(3,4-dichlorophenyl)methyl]-N-[(4-methylphenyl)methyl]-, hydrochloride (1:1), (5R)- | CAS: | 2319838-09-8 | MF: | C24H30Cl3N3O | MW: | 482.87 | EINECS: | | Product Categories: | | Mol File: | 2319838-09-8.mol | ![2,7-Diazaspiro[4.5]decane-7-carboxamide, 2-[(3,4-dichlorophenyl)methyl]-N-[(4-methylphenyl)methyl]-, hydrochloride (1:1), (5R)- Structure](CAS/20211123/GIF/2319838-09-8.gif) |
| 2,7-Diazaspiro[4.5]decane-7-carboxamide, 2-[(3,4-dichlorophenyl)methyl]-N-[(4-methylphenyl)methyl]-, hydrochloride (1:1), (5R)- Chemical Properties |
| 2,7-Diazaspiro[4.5]decane-7-carboxamide, 2-[(3,4-dichlorophenyl)methyl]-N-[(4-methylphenyl)methyl]-, hydrochloride (1:1), (5R)- Usage And Synthesis |
Uses | GSK2850163 hydrochloride is a novel inhibitor of inositol-requiring enzyme-1 alpha (IRE1α) which can inhibit IRE1α kinase activity and RNase activity with IC50s of 20 and 200 nM, respectively. | References | [1] Nestor O. Concha, et al. Long-Range Inhibitor-Induced Conformational Regulation of Human IRE1α Endoribonuclease Activity. Molecular Pharmacology December 2015, 88 (6) 1011-1023. |
| 2,7-Diazaspiro[4.5]decane-7-carboxamide, 2-[(3,4-dichlorophenyl)methyl]-N-[(4-methylphenyl)methyl]-, hydrochloride (1:1), (5R)- Preparation Products And Raw materials |
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