| Company Name: |
TargetMol Chemicals Inc.
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| Tel: |
15002134094 |
| Email: |
marketing@targetmol.cn |
| Products Intro: |
Product Name:KUNB31
CAS:2220263-80-7
Package:50mg/RMB 15300;25mg/RMB 11700;100mg/RMB 19500
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KUNB 31 manufacturers
- KUNB31
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- $2180.00 / 50mg
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2024-10-28
- CAS:2220263-80-7
- Min. Order:
- Purity:
- Supply Ability: 10g
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| | KUNB 31 Basic information |
| Product Name: | KUNB 31 | | Synonyms: | KUNB 31;Methanone, (1,3-dihydro-2H-isoindol-2-yl)[4-hydroxy-7-(1-methylethyl)-1,2-benzisoxazol-5-yl]- | | CAS: | 2220263-80-7 | | MF: | C19H18N2O3 | | MW: | 322.36 | | EINECS: | | | Product Categories: | | | Mol File: | 2220263-80-7.mol |  |
| | KUNB 31 Chemical Properties |
| Boiling point | 544.1±50.0 °C(Predicted) | | density | 1.314±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | DMSO: 2mg/mL, clear | | pka | 6.92±0.50(Predicted) | | form | powder | | color | white to beige |
| | KUNB 31 Usage And Synthesis |
| Biological Activity | KUNB31 is an isoform-selective inhibitor of Hsp90β with an IC50 value of 180 nM and > 50-fold selectivity over closely related isoforms Hsp90α and GRP94.Hsp90 inhibitors currently in clinical trials are all pan-inhibitors with multiple side effects including induction of the pro-survival he at shock response. KUNB31 was shown to induce the degradation of Hsp90β-dependent client proteins, but not those of Hsp90α and GRP94, and did not induce production of Hsp90. It showed anti-proliferative activity against NCI H23 (non-small cell lung cancer), UC3 (bladder cancer), and HT-29 (colon adenocarcinoma) cells with low micromolar IC50 values, while requiring more than 100 μM against non-cancerous human embryonic kidney HEK-293 cells. |
| | KUNB 31 Preparation Products And Raw materials |
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