L-Threonine, N-acetyl-L-threonyl-(αR)-α-hydroxybenzenepropanoyl-2,3-didehydro-N-methylalanyl-L-alanyl-N-methyl-L-alanyl-(3R)-3-[[(2S,3R)-2-(acetylamino)-3-hydroxy-4-methyl-1-oxopentyl]oxy]-L-leucyl-N,O-dimethyl-, (7→1)-lactone
| 中文名稱 | L-Threonine, N-acetyl-L-threonyl-(αR)-α-hydroxybenzenepropanoyl-2,3-didehydro-N-methylalanyl-L-alanyl-N-methyl-L-alanyl-(3R)-3-[[(2S,3R)-2-(acetylamino)-3-hydroxy-4-methyl-1-oxopentyl]oxy]-L-leucyl-N,O-dimethyl-, (7→1)-lactone |
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| 中文同義詞 | 化合物 T17273;L-THREONINE, N-ACETYL-L-THREONYL-(ΑR)-Α-HYDROXYBENZENEPROPANOYL-2,3-DIDEHYDRO-N-METHYLALANYL-L-ALANYL-N-METHYL-L-ALANYL-(3R)-3-[[(2S,3R)-2-(ACETYLAMINO)-3-HYDROXY-4-METHYL-1-OXOPENTYL]OXY]-L-LEUCYL-N,O-DIMETHYL-, (7→1)-LACTONE;化合物 YM-254890 |
| 英文名稱 | L-Threonine, N-acetyl-L-threonyl-(αR)-α-hydroxybenzenepropanoyl-2,3-didehydro-N-methylalanyl-L-alanyl-N-methyl-L-alanyl-(3R)-3-[[(2S,3R)-2-(acetylamino)-3-hydroxy-4-methyl-1-oxopentyl]oxy]-L-leucyl-N,O-dimethyl-, (7→1)-lactone |
| 英文同義詞 | L-Threonine, N-acetyl-L-threonyl-(αR)-α-hydroxybenzenepropanoyl-2,3-didehydro-N-methylalanyl-L-alanyl-N-methyl-L-alanyl-(3R)-3-[[(2S,3R)-2-(acetylamino)-3-hydroxy-4-methyl-1-oxopentyl]oxy]-L-leucyl-N,O-dimethyl-, (7→1)-lactone |
| CAS號(hào) | 568580-02-9 |
| 分子式 | C46H69N7O15 |
| 分子量 | 960.09 |
| EINECS號(hào) | |
| 相關(guān)類別 | |
| Mol文件 | 568580-02-9.mol |
| 結(jié)構(gòu)式 | ![L-Threonine, N-acetyl-L-threonyl-(αR)-α-hydroxybenzenepropanoyl-2,3-didehydro-N-methylalanyl-L-alanyl-N-methyl-L-alanyl-(3R)-3-[[(2S,3R)-2-(acetylamino)-3-hydroxy-4-methyl-1-oxopentyl]oxy]-L-leucyl-N,O-dimethyl-, (7→1)-lactone 結(jié)構(gòu)式](CAS/20211123/GIF/568580-02-9.gif) |
L-Threonine, N-acetyl-L-threonyl-(αR)-α-hydroxybenzenepropanoyl-2,3-didehydro-N-methylalanyl-L-alanyl-N-methyl-L-alanyl-(3R)-3-[[(2S,3R)-2-(acetylamino)-3-hydroxy-4-methyl-1-oxopentyl]oxy]-L-leucyl-N,O-dimethyl-, (7→1)-lactone 性質(zhì)
| 沸點(diǎn) | 1232.4±65.0 °C(Predicted) |
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| 密度 | 1.26±0.1 g/cm3(Predicted) |
| 儲(chǔ)存條件 | -20°C |
| 溶解度 | 溶于DMSO（高達(dá)10mg/ml） |
| 形態(tài) | 凍干固體 |
| 酸度系數(shù)(pKa) | 12.52±0.70(Predicted) |
| 顏色 | 白色或灰白色 |
| 穩(wěn)定性 | 可在-20°C下的DMSO溶液保存長(zhǎng)達(dá)1個(gè)月。 |
L-Threonine, N-acetyl-L-threonyl-(αR)-α-hydroxybenzenepropanoyl-2,3-didehydro-N-methylalanyl-L-alanyl-N-methyl-L-alanyl-(3R)-3-[[(2S,3R)-2-(acetylamino)-3-hydroxy-4-methyl-1-oxopentyl]oxy]-L-leucyl-N,O-dimethyl-, (7→1)-lactone 用途與合成方法
G αq/11 protein
YM-254890 inhibits platelet aggregation induced by ADP (2, 5 and 20 μM) in human platelet-rich plasma with IC 50 values of 0.37, 0.39 and 0.51 μM. ADP mediates platelet aggregation via two G protein-coupled receptors, P2Y 1 and P2Y 12 . The effect of YM-254890 on the P2Y 1 and P2Y 12 signal transduction pathways using C6-15 cells stably expressing the human P2Y 1 or P2Y 12 receptors is examined. Stimulation of P2Y 1 -C6-15 cells by 2MeSADP leads to increases in intracellular calcium mobilization. In this assay, YM-254890 inhibits the increase in [Ca 2+ ] i with an IC 50 value of 0.031 μM. In contrast, 2MeSADP-induced inhibition of forskolin-stimulated adenylyl cyclase activity in P2Y 12 -C6-15 cells is unaffected by YM-254890 at 40 μM.