| Company Name: |
Hefei fuya biotechnology co. LTD
|
| Tel: |
18096409024 |
| Email: |
sales02@foreversyn.com |
| Products Intro: |
Product Name:(Rac)-BRD0705
CAS:1597440-03-3
Purity:95% HPLC Package:100mg;500mg
|
(Rac)-BRD0705 manufacturers
- (Rac)-BRD0705
-
- $88.00 / 1mg
-
2024-11-19
- CAS:1597440-03-3
- Min. Order:
- Purity: 99.67%
- Supply Ability: 10g
- (Rac)-BRD0705
-
- $88.00 / 1mg
-
2024-11-19
- CAS:1597440-03-3
- Min. Order:
- Purity: 99.67%
- Supply Ability: 10g
|
| | (Rac)-BRD0705 Basic information |
| Product Name: | (Rac)-BRD0705 | | Synonyms: | (Rac)-BRD0705;GSK3α,inhibit,Racemate,(Rac)BRD0705,GSK-3,Inhibitor,Glycogen synthase kinase-3,(Rac) BRD0705,(Rac)-BRD-0705,Glycogen synthase kinase 3,(Rac)-BRD0705;5H-Pyrazolo[3,4-b]quinolin-5-one, 4-ethyl-1,2,4,6,7,8-hexahydro-7,7-dimethyl-4-phenyl-;(Rac)-BRD0705, 10 mM in DMSO | | CAS: | 1597440-03-3 | | MF: | C20H23N3O | | MW: | 321.42 | | EINECS: | | | Product Categories: | | | Mol File: | 1597440-03-3.mol |  |
| | (Rac)-BRD0705 Chemical Properties |
| Boiling point | 512.0±50.0 °C(Predicted) | | density | 1.22±0.1 g/cm3(Predicted) | | pka | 14.82±0.60(Predicted) | | form | Solid | | color | Light yellow to yellow |
| | (Rac)-BRD0705 Usage And Synthesis |
| Uses | (Rac)-BRD0705 is a less active racemate of BRD0705. BRD0705 is a potent, paralog selective and orally active GSK3α inhibitor with an IC50 of 66 nM and a Kd of 4.8 μM. BRD0705 displays increased selectivity for GSK3α (8-fold) versus GSK3β (IC50 of 515 nM). BRD0705 can be used for acute myeloid leukemia (AML)[1][2]. | | References | [1] Wagner FF, et al. Exploiting an Asp-Glu "switch" in glycogen synthase kinase 3 to design paralog-selective inhibitors for use in acute myeloid leukemia. Sci Transl Med. 2018 Mar 7;10(431). pii: eaam8460. DOI:10.1126/scitranslmed.aam8460
[2] Edward Scolnick, et al. Uses of paralog-selective inhibitors of gsk3 kinases. US20160375006A1. |
| | (Rac)-BRD0705 Preparation Products And Raw materials |
|