脫乙基氯喹二磷酸鹽
| 中文名稱(chēng) | 脫乙基氯喹二磷酸鹽 |
|---|---|
| 中文同義詞 | 脫乙基氯喹二磷酸鹽;化合物 T11001L;化合物 DESETHYL CHLOROQUINE DIPHOSPHATE |
| 英文名稱(chēng) | Desethylchloroquine diphosphate salt |
| 英文同義詞 | Desethylchloroquine diphosphate salt;Desethyl chloroquine diphosphate |
| CAS號(hào) | 247912-76-1 |
| 分子式 | C16H25ClN3O4P |
| 分子量 | 389.82 |
| EINECS號(hào) | |
| 相關(guān)類(lèi)別 | |
| Mol文件 | 247912-76-1.mol |
| 結(jié)構(gòu)式 |  |
脫乙基氯喹二磷酸鹽 性質(zhì)
| 儲(chǔ)存條件 | 4°C, protect from light, stored under nitrogen |
|---|---|
| 溶解度 | 溶于二甲基亞砜 |
| 形態(tài) | 固體 |
| 顏色 | 白色至米白色 |
Desethyl chloroquine diphosphate 是 Chloroquine 的主要去乙基代謝產(chǎn)物。Chloroquine 是一種自噬和 toll-like receptors (TLRs) 的抑制劑。Desethyl chloroquine diphosphate 具有抗瘧原蟲(chóng)活性。
P. falciparum
Intraperitoneal injections of Chloroquine are administered to wild-type and Huntington's disease (Q175/Q175) mice. LC-MS/MS is used to compare the levels Chloroquine and its metabolites in blood, brain and muscle tissue. Concentrations of Chloroquine are lower (5-15M), but more stable in brain tissue compared to blood or muscle between 4 and 24 hours after the last dose. Levels of the active Chloroquine metabolite Desethyl chloroquine decreased in muscle and blood over the 24 hour post-injection period, while brain Desethyl chloroquine levels are lower and rose slightly over the same time frame.
安全信息
| 更新日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱(chēng) | CAS號(hào) | 包裝 | 價(jià)格 |
|---|---|---|---|---|---|
| 2024/11/08 | HY-135811A | Desethyl chloroquine diphosphate | 1 mg | 1818元 | |
| 2024/11/08 | HY-135811A | 脫乙基氯喹二磷酸鹽 Desethyl chloroquine diphosphate | 247912-76-1 | 5mg | 4000元 |