Amyloid β-Protein (1-42) (mouse, rat) manufacturers
- Beta-Amyloid 1-42
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- $1.00 / 1MG
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2018-06-12
- CAS:107761-42-2
- Min. Order: 1MG
- Purity: >95%HPLC
- Supply Ability: 1mg,5mg,10mg,25mg,100mg,1g,10g
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| | Amyloid β-Protein (1-42) (mouse, rat) Basic information |
| Product Name: | Amyloid β-Protein (1-42) (mouse, rat) | | Synonyms: | ASP-ALA-GLU-PHE-ARG-HIS-ASP-SER-GLY-TYR-GLU-VAL-HIS-HIS-GLN-LYS-LEU-VAL-PHE-PHE-ALA-GLU-ASP-VAL-GLY-SER-ASN-LYS-GLY-ALA-ILE-ILE-GLY-LEU-MET-VAL-GLY-GLY-VAL-VAL-ILE-ALA;ASP-ALA-GLU-PHE-GLY-HIS-ASP-SER-GLY-PHE-GLU-VAL-ARG-HIS-GLN-LYS-LEU-VAL-PHE-PHE-ALA-GLU-ASP-VAL-GLY-SER-ASN-LYS-GLY-ALA-ILE-ILE-GLY-LEU-MET-VAL-GLY-GLY-VAL-VAL-ILE-ALA;BAP 1-42;BETA-AMYLOID, SODIUM SALT;AMyloid b-Protein (1-42) (Mouse, rat);PREDOMINANT AMYLOID B-PROTEIN FRAGMENT;767: PN: US20090175821 SEQID: 961 claimed protein;Amyloid beta-peptide (1-42) (rat) | | CAS: | 166090-74-0 | | MF: | C203H311N55O60S | | MW: | 0 | | EINECS: | | | Product Categories: | peptide;Neuroscience | | Mol File: | Mol File | ![Amyloid β-Protein (1-42) (mouse, rat) Structure]() |
| | Amyloid β-Protein (1-42) (mouse, rat) Chemical Properties |
| storage temp. | −20°C | | solubility | Soluble in DMSO | | form | Solid | | color | White to off-white | | Sequence | Asp-Ala-Glu-Phe-Gly-His-Asp-Ser-Gly-Phe-Glu-Val-Arg-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala |
| | Amyloid β-Protein (1-42) (mouse, rat) Usage And Synthesis |
| Uses | Substrate Cleavage Assays (30-100 μg/ml) | | Biological Activity | Amyloid beta-peptide (1-42) (rat) is a 42 amino acid polypeptide that is toxic to hippocampal slices and can be used in Alzheimer's disease research. | | in vivo | β-Amyloid (1-42), (rat/mouse) can induce Alzheimer's disease[4].
Induction of Alzheimer's disease[4] Background
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder mainly characterized by the abnormal accumulation of β-amyloid (Aβ) peptide. The oligomeric form of the Aβ peptide as being the critical initiator of neurotoxicity in the AD pathogenesis[4].
Specific Modeling Methods
Rat: Wistar ? male ? adult, weighing 240-260 g
Administration: 1 μg/μL ? Hippocampal injection ? single dose
Note
(1) β-Amyloid (1-42) needs to be processed into oligomers before use.
(2) β-Amyloid (1-42) was injected bilaterally into the hippocampus of rat brain in a volume of 1.0 μL over a period of 0.1 μL/min using 1 μL Hamilton syringe.
Modeling Indicators Indicator changes: Decreased the gene expression level of α7-nAChR and increased the mRNA expression of NMDA receptor 2A, and -2B subunits.
Behavior: β-Amyloid (1-42) aggregates increased the retention time and altered the behavioral response in rats after 15 days of injection.
Correlated Product(s): β-Amyloid (1-42), (rat/mouse) TFA (HY-P1388A);
β-Amyloid (1-40) (rat) (HY-P1387);
β-Amyloid (1-40) TFA (HY-P0265A) Opposite Product(s): / | | target | | | storage | Store at -20°C |
| | Amyloid β-Protein (1-42) (mouse, rat) Preparation Products And Raw materials |
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