1-(5'-((1-(4-chloro-3-methylphenyl)ethyl)amino)-2'-fluoro-3,5-dimethyl-[1,1'-biphenyl]-4-carboxamido)cyclopropane-1-carboxylic acid
| 中文名稱(chēng) | 1-(5'-((1-(4-chloro-3-methylphenyl)ethyl)amino)-2'-fluoro-3,5-dimethyl-[1,1'-biphenyl]-4-carboxamido)cyclopropane-1-carboxylic acid |
|---|---|
| 中文同義詞 | 化合物 T28643;化合物 EX26;1-(5'-((1-(4-CHLORO-3-METHYLPHENYL)ETHYL)AMINO)-2'-FLUORO-3,5-DIMETHYL-[1,1'-BIPHENYL]-4-CARBOXAMIDO)CYCLOPROPANE-1-CARBOXYLIC ACID |
| 英文名稱(chēng) | 1-(5'-((1-(4-chloro-3-methylphenyl)ethyl)amino)-2'-fluoro-3,5-dimethyl-[1,1'-biphenyl]-4-carboxamido)cyclopropane-1-carboxylic acid |
| 英文同義詞 | 1-(5'-((1-(4-chloro-3-methylphenyl)ethyl)amino)-2'-fluoro-3,5-dimethyl-[1,1'-biphenyl]-4-carboxamido)cyclopropane-1-carboxylic acid;S1P1-IN-Ex26;Ex 26;1-({5'-[1-(4-Chloro-3-methyl-phenyl)-ethylamino]-2'-fluoro-3,5-dimethyl-biphenyl-4-carbonyl}-amino)-cyclopropanecarboxylic acid;1-[[[5'-[[1-(4-Chloro-3-methylphenyl)ethyl]amino]-2'-fluoro-3,5-dimethyl[1,1'-biphenyl]-4-yl]carbonyl]amino]-cyclopropanecarboxylic acid;Cyclopropanecarboxylic acid, 1-[[[5'-[[1-(4-chloro-3-methylphenyl)ethyl]amino]-2'-fluoro-3,5-dimethyl[1,1'-biphenyl]-4-yl]carbonyl]amino]-;Ex26 >=98% (HPLC);S1P1 IN Ex26,S-1P1-IN-Ex26,S1P1INEx26 |
| CAS號(hào) | 1233332-37-0 |
| 分子式 | C28H28ClFN2O3 |
| 分子量 | 494.98 |
| EINECS號(hào) | |
| 相關(guān)類(lèi)別 | |
| Mol文件 | 1233332-37-0.mol |
| 結(jié)構(gòu)式 | ![1-(5'-((1-(4-chloro-3-methylphenyl)ethyl)amino)-2'-fluoro-3,5-dimethyl-[1,1'-biphenyl]-4-carboxamido)cyclopropane-1-carboxylic acid 結(jié)構(gòu)式](CAS/20180527/GIF/1233332-37-0.gif) |
1-(5'-((1-(4-chloro-3-methylphenyl)ethyl)amino)-2'-fluoro-3,5-dimethyl-[1,1'-biphenyl]-4-carboxamido)cyclopropane-1-carboxylic acid 性質(zhì)
| 儲(chǔ)存條件 | Store at -20°C |
|---|---|
| 溶解度 | 溶于二甲基亞砜 |
| 形態(tài) | powder |
| 顏色 | white to beige |
1-(5'-((1-(4-chloro-3-methylphenyl)ethyl)amino)-2'-fluoro-3,5-dimethyl-[1,1'-biphenyl]-4-carboxamido)cyclopropane-1-carboxylic acid 用途與合成方法
Ex26 (S1P1-IN-Ex26) 是一種強(qiáng)效和選擇性的 sphingosine 1-phosphate receptor 1 (S1P1) 拮抗劑 (IC50=0.93 nM)，對(duì) S1P1 的選擇性大于其他 Sphingosine 1-phosphate receptor 約 3,000 倍。Ex26 可用于實(shí)驗(yàn)性自身免疫性腦脊髓炎的研究。